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GTF2A1L Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q9UNN4 |
|---|---|
| Clone Names | 100517148 |
| Gene ID | 11036 |
|---|---|
| Other Names | TFIIA-alpha and beta-like factor, General transcription factor II A, 1-like factor, GTF2A1L, ALF, GTF2A1LF |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | GTF2A1L |
|---|---|
| Synonyms | ALF, GTF2A1LF |
| Function | May function as a testis specific transcription factor. Binds DNA in conjunction with GTF2A2 and TBP (the TATA-binding protein) and together with GTF2A2, allows mRNA transcription. |
| Cellular Location | Nucleus. Note=Mainly localizes in the annulus and partly in acrosomal cap area of spermatozoa |
| Tissue Location | Testis specific. Detected in adult testis mostly in round and elongating spermatids (at protein level). Detected in testis |
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Provided below are standard protocols that you may find useful for product applications.
Background
The assembly and stability of the RNA polymerase IItranscription pre-initiation complex on a eukaryotic core promoterinvolve the effects of TFIIA on the interaction betweenTATA-binding protein (TBP) and DNA. This gene encodes a germcell-specific counterpart of the large (alpha/beta) subunit ofgeneral transcription factor TFIIA that is able to stabilize thebinding of TBP to DNA and may be uniquely important to testisbiology. Alternative splicing for this locus has been observed andtwo variants, encoding distinct isoforms, have been identified.Co-transcription of this gene and the neighboring upstream genegenerates a rare transcript (SALF), which encodes a fusion proteincomprised of sequence sharing identity with each individual geneproduct.
References
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Kim, M., et al. J. Biol. Chem. 281(45):34288-34298(2006)Howe, M.L., et al. Stem Cells Dev. 15(2):175-190(2006)Huang, M., et al. Int. J. Mol. Med. 17(4):599-604(2006)Upadhyaya, A.B., et al. J. Biol. Chem. 277(37):34208-34216(2002)
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