|Other Names||TFIIA-alpha and beta-like factor, General transcription factor II A, 1-like factor, GTF2A1L, ALF, GTF2A1LF|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||May function as a testis specific transcription factor. Binds DNA in conjunction with GTF2A2 and TBP (the TATA-binding protein) and together with GTF2A2, allows mRNA transcription.|
|Cellular Location||Nucleus. Note=Mainly localizes in the annulus and partly in acrosomal cap area of spermatozoa|
|Tissue Location||Testis specific. Detected in adult testis mostly in round and elongating spermatids (at protein level) Detected in testis.|
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The assembly and stability of the RNA polymerase IItranscription pre-initiation complex on a eukaryotic core promoterinvolve the effects of TFIIA on the interaction betweenTATA-binding protein (TBP) and DNA. This gene encodes a germcell-specific counterpart of the large (alpha/beta) subunit ofgeneral transcription factor TFIIA that is able to stabilize thebinding of TBP to DNA and may be uniquely important to testisbiology. Alternative splicing for this locus has been observed andtwo variants, encoding distinct isoforms, have been identified.Co-transcription of this gene and the neighboring upstream genegenerates a rare transcript (SALF), which encodes a fusion proteincomprised of sequence sharing identity with each individual geneproduct.
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Kim, M., et al. J. Biol. Chem. 281(45):34288-34298(2006)Howe, M.L., et al. Stem Cells Dev. 15(2):175-190(2006)Huang, M., et al. Int. J. Mol. Med. 17(4):599-604(2006)Upadhyaya, A.B., et al. J. Biol. Chem. 277(37):34208-34216(2002)
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