|Other Names||LIM domain-binding protein 2, LDB-2, Carboxyl-terminal LIM domain-binding protein 1, CLIM-1, LIM domain-binding factor CLIM1, LDB2, CLIM1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Binds to the LIM domain of a wide variety of LIM domain- containing transcription factors.|
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Provided below are standard protocols that you may find useful for product applications.
Genes encoding LIM domain-binding factors were initiallyisolated in a screen for proteins that physically interact with theLIM domains of nuclear proteins (summarized by Semina et al., 1998[PubMed 9799849]). These proteins, such as the one encoded by theLDB2 gene, are capable of binding to a variety of transcriptionfactors and are likely to function at enhancers to bring togetherdiverse transcription factors and form higher order activationcomplexes or to block formation of such complexes (Jurata and Gill,1997 [PubMed 9315627]). The family of genes encoding LIMdomain-binding factors includes 2 members isolated from the mouse,Clim1 (Bach et al., 1997 [PubMed 9192866]) and Clim2/Lbd1/Nli(Agulnick et al., 1996 [PubMed 8918878]; Jurata et al., 1996[PubMed 8876198]; Bach et al., 1997 [PubMed 9192866]) and theirhomologs cloned from the frog, chicken, and fly. The fact that LIMdomain-binding factors are likely to be involved in thecoordination of the transcriptional activity of many diversefactors might implicate them in human phenotypes characterized bymultiple affected sites.
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Hagg, S., et al. PLoS Genet. 5 (12), E1000754 (2009) :Colland, F., et al. Genome Res. 14(7):1324-1332(2004)Kotaka, M., et al. J. Cell. Biochem. 78(4):558-565(2000)Bach, I., et al. Nat. Genet. 22(4):394-399(1999)
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