|Other Names||Ubiquitin-conjugating enzyme E2 J1, Non-canonical ubiquitin-conjugating enzyme 1, NCUBE-1, Yeast ubiquitin-conjugating enzyme UBC6 homolog E, HsUBC6e, UBE2J1, NCUBE1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Catalyzes the covalent attachment of ubiquitin to other proteins. Functions in the selective degradation of misfolded membrane proteins from the endoplasmic reticulum (ERAD).|
|Cellular Location||Endoplasmic reticulum membrane; Single-pass type IV membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
The modification of proteins with ubiquitin is animportant cellular mechanism for targeting abnormal or short-livedproteins for degradation. Ubiquitination involves at least threeclasses of enzymes: ubiquitin-activating enzymes, or E1s,ubiquitin-conjugating enzymes, or E2s, and ubiquitin-proteinligases, or E3s. This gene encodes a member of the E2ubiquitin-conjugating enzyme family. This enzyme is located in themembrane of the endoplasmic reticulum (ER) and may contribute toquality control ER-associated degradation by theubiquitin-proteasome system.
Pattaro, C., et al. BMC Med. Genet. 11, 41 (2010) :Olsen, J.V., et al. Cell 127(3):635-648(2006)Oh, R.S., et al. J. Biol. Chem. 281(30):21480-21490(2006)Wu, C.J., et al. EMBO J. 24(10):1886-1898(2005)Mungall, A.J., et al. Nature 425(6960):805-811(2003)
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