FOXK2 Antibody (N-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q01167 |
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Clone Names | 100517192 |
Gene ID | 3607 |
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Other Names | Forkhead box protein K2, Cellular transcription factor ILF-1, FOXK1, Interleukin enhancer-binding factor 1, FOXK2, ILF, ILF1 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | FOXK2 |
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Function | Transcriptional regulator involved in different processes such as glucose metabolism, aerobic glycolysis and autophagy (By similarity). Recognizes and binds the forkhead DNA sequence motif (5'- GTAAACA-3') and can both act as a transcription activator or repressor, depending on the context (PubMed:22083952, PubMed:25451922). Together with FOXK1, acts as a key regulator of metabolic reprogramming towards aerobic glycolysis, a process in which glucose is converted to lactate in the presence of oxygen (By similarity). Acts by promoting expression of enzymes for glycolysis (such as hexokinase-2 (HK2), phosphofructokinase, pyruvate kinase (PKLR) and lactate dehydrogenase), while suppressing further oxidation of pyruvate in the mitochondria by up-regulating pyruvate dehydrogenase kinases PDK1 and PDK4 (By similarity). Probably plays a role in gluconeogenesis during overnight fasting, when lactate from white adipose tissue and muscle is the main substrate (By similarity). Together with FOXK1, acts as a negative regulator of autophagy in skeletal muscle: in response to starvation, enters the nucleus, binds the promoters of autophagy genes and represses their expression, preventing proteolysis of skeletal muscle proteins (By similarity). In addition to the 5'-GTAAACA-3' DNA motif, also binds the 5'-TGANTCA-3' palindromic DNA motif, and co-associates with JUN/AP-1 to activate transcription (PubMed:22083952). Also able to bind to a minimal DNA heteroduplex containing a G/T-mismatch with 5'- TRT[G/T]NB-3' sequence (PubMed:20097901). Binds to NFAT-like motifs (purine-rich) in the IL2 promoter (PubMed:1339390). Positively regulates WNT/beta-catenin signaling by translocating DVL proteins into the nucleus (PubMed:25805136). Also binds to HIV-1 long terminal repeat. May be involved in both positive and negative regulation of important viral and cellular promoter elements (PubMed:1909027). |
Cellular Location | Nucleus. Cytoplasm {ECO:0000250|UniProtKB:Q3UCQ1} |
Tissue Location | Expressed in both lymphoid and non-lymphoid cells. |
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene contains a fork head DNAbinding domain. This protein can bind to the purine-rich motifs ofthe HIV long terminal repeat (LTR), and to the similar purine-richmotif in the interleukin 2 (IL2) promoter. It may be involved inthe regulation of viral and cellular promoter elements. [providedby RefSeq].
References
Fujii, Y., et al. J. Biochem. 147(5):705-709(2010)Sugiyama, N., et al. Mol. Cell Proteomics 6(6):1103-1109(2007)Matsuoka, S., et al. Science 316(5828):1160-1166(2007)Beausoleil, S.A., et al. Nat. Biotechnol. 24(10):1285-1292(2006)Tsai, K.L., et al. J. Biol. Chem. 281(25):17400-17409(2006)
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