|Other Names||Nicotinate-nucleotide pyrophosphorylase [carboxylating], Quinolinate phosphoribosyltransferase [decarboxylating], QAPRTase, QPRTase, QPRT|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Involved in the catabolism of quinolinic acid (QA).|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a key enzyme in catabolism ofquinolinate, an intermediate in the tryptophan-nicotinamide adeninedinucleotide pathway. Quinolinate acts as a most potent endogenousexitotoxin to neurons. Elevation of quinolinate levels in the brainhas been linked to the pathogenesis of neurodegenerative disorderssuch as epilepsy, Alzheimer's disease, and Huntington's disease.
Hinsch, N., et al. BMC Cancer 9, 93 (2009) :Liu, H., et al. J. Mol. Biol. 373(3):755-763(2007)Magni, G., et al. Cell. Mol. Life Sci. 61(1):19-34(2004)Fukuoka, S., et al. Adv. Exp. Med. Biol. 467, 611-614 (1999) :Fukuoka, S.I., et al. Biochim. Biophys. Acta 1395(2):192-201(1998)
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