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METAP2 Antibody (N-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession P50579
Clone Names 100517303
Peptide ID 100517303
Additional Information
Gene ID 10988
Other Names Methionine aminopeptidase 2 {ECO:0000255|HAMAP-Rule:MF_03175}, MAP 2 {ECO:0000255|HAMAP-Rule:MF_03175}, MetAP 2 {ECO:0000255|HAMAP-Rule:MF_03175}, 341118 {ECO:0000255|HAMAP-Rule:MF_03175}, Initiation factor 2-associated 67 kDa glycoprotein {ECO:0000255|HAMAP-Rule:MF_03175}, p67 {ECO:0000255|HAMAP-Rule:MF_03175}, p67eIF2 {ECO:0000255|HAMAP-Rule:MF_03175}, Peptidase M {ECO:0000255|HAMAP-Rule:MF_03175}, METAP2 {ECO:0000255|HAMAP-Rule:MF_03175}
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name METAP2 {ECO:0000255|HAMAP-Rule:MF_03175}
Function Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). The catalytic activity of human METAP2 toward Met-Val peptides is consistently two orders of magnitude higher than that of METAP1, suggesting that it is responsible for processing proteins containing N- terminal Met-Val and Met-Thr sequences in vivo.
Cellular Location Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03175, ECO:0000269|PubMed:21537465}. Note=About 30% of expressed METAP2 associates with polysomes
Research Areas
Citations (0)

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This gene is a member of the methionyl aminopeptidasefamily and encodes a protein that binds 2 cobalt or manganese ions.This protein functions both by protecting the alpha subunit ofeukaryotic initiation factor 2 from inhibitory phosphorylation andby removing the amino-terminal methionine residue from nascentprotein. Increased expression of this gene is associated withvarious forms of cancer and the anti-cancer drugs fumagillin andovalicin inhibit the protein by irreversibly binding to its activesite. A pseudogene of this gene is located on chromosome 2.


Xiao, Q., et al. Biochemistry 49(26):5588-5599(2010)Wang, X., et al. PLoS ONE 5 (8), E11934 (2010) :Selvakumar, P., et al. Mol. Cancer 8, 65 (2009) :Warder, S.E., et al. J. Proteome Res. 7(11):4807-4820(2008)Tucker, L.A., et al. Oncogene 27(28):3967-3976(2008)

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$ 80.00
Cat# BP14389a
Availability: In Stock
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