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METAP2 Antibody (N-term) Blocking Peptide
Synthetic peptide
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- BACKGROUND
| Primary Accession | P50579 |
|---|---|
| Clone Names | 100517303 |
| Gene ID | 10988 |
|---|---|
| Other Names | Methionine aminopeptidase 2 {ECO:0000255|HAMAP-Rule:MF_03175}, MAP 2 {ECO:0000255|HAMAP-Rule:MF_03175}, MetAP 2 {ECO:0000255|HAMAP-Rule:MF_03175}, 341118 {ECO:0000255|HAMAP-Rule:MF_03175}, Initiation factor 2-associated 67 kDa glycoprotein {ECO:0000255|HAMAP-Rule:MF_03175}, p67 {ECO:0000255|HAMAP-Rule:MF_03175}, p67eIF2 {ECO:0000255|HAMAP-Rule:MF_03175}, Peptidase M {ECO:0000255|HAMAP-Rule:MF_03175}, METAP2 {ECO:0000255|HAMAP-Rule:MF_03175} |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | METAP2 {ECO:0000255|HAMAP-Rule:MF_03175} |
|---|---|
| Synonyms | MNPEP, P67EIF2 |
| Function | Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met- Ala-, Cys, Gly, Pro, Ser, Thr, or Val). The catalytic activity of human METAP2 toward Met-Val peptides is consistently two orders of magnitude higher than that of METAP1, suggesting that it is responsible for processing proteins containing N-terminal Met-Val and Met-Thr sequences in vivo. |
| Cellular Location | Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03175, ECO:0000269|PubMed:21537465}. Note=About 30% of expressed METAP2 associates with polysomes |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene is a member of the methionyl aminopeptidasefamily and encodes a protein that binds 2 cobalt or manganese ions.This protein functions both by protecting the alpha subunit ofeukaryotic initiation factor 2 from inhibitory phosphorylation andby removing the amino-terminal methionine residue from nascentprotein. Increased expression of this gene is associated withvarious forms of cancer and the anti-cancer drugs fumagillin andovalicin inhibit the protein by irreversibly binding to its activesite. A pseudogene of this gene is located on chromosome 2.
References
Xiao, Q., et al. Biochemistry 49(26):5588-5599(2010)Wang, X., et al. PLoS ONE 5 (8), E11934 (2010) :Selvakumar, P., et al. Mol. Cancer 8, 65 (2009) :Warder, S.E., et al. J. Proteome Res. 7(11):4807-4820(2008)Tucker, L.A., et al. Oncogene 27(28):3967-3976(2008)
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