|Other Names||Minor histocompatibility antigen H13, 3423-, Intramembrane protease 1, IMP-1, IMPAS-1, hIMP1, Presenilin-like protein 3, Signal peptide peptidase, HM13, H13, IMP1, PSL3, SPP|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||H13, IMP1, PSL3, SPP|
|Function||Catalyzes intramembrane proteolysis of some signal peptides after they have been cleaved from a preprotein, resulting in the release of the fragment from the ER membrane into the cytoplasm. Required to generate lymphocyte cell surface (HLA-E) epitopes derived from MHC class I signal peptides. May play a role in graft rejection (By similarity). May be necessary for the removal of the signal peptide that remains attached to the hepatitis C virus core protein after the initial proteolytic processing of the polyprotein. Involved in the intramembrane cleavage of the integral membrane protein PSEN1 (PubMed:11714810, PubMed:12077416, PubMed:12145199, PubMed:14741365). Cleaves the integral membrane protein XBP1 isoform 1 in a DERL1/RNF139- dependent manner (PubMed:25239945).|
|Cellular Location||Endoplasmic reticulum membrane; Multi-pass membrane protein|
|Tissue Location||Widely expressed with highest levels in kidney, liver, placenta, lung, leukocytes and small intestine and reduced expression in heart and skeletal muscle. Expressed abundantly in the CNS with highest levels in thalamus and medulla|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene, which localizes to theendoplasmic reticulum, catalyzes intramembrane proteolysis of somesignal peptides after they have been cleaved from a preprotein.This activity is required to generate signal sequence-derived humanlymphocyte antigen-E epitopes that are recognized by the immunesystem, and to process hepatitis C virus core protein. The encodedprotein is an integral membrane protein with sequence motifscharacteristic of the presenilin-type aspartic proteases. Multipletranscript variants encoding several different isoforms have beenfound for this gene.
Sato, T., et al. Biochemistry 45(28):8649-8656(2006)Loureiro, J., et al. Nature 441(7095):894-897(2006)Urny, J., et al. Biochim. Biophys. Acta 1759 (3-4), 159-165 (2006) :Friedmann, E., et al. J. Biol. Chem. 279(49):50790-50798(2004)Soares, M.R., et al. FEBS Lett. 560 (1-3), 134-140 (2004) :
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