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HM13 Antibody (C-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q8TCT9
Clone Names 100517320
Peptide ID 100517320
Additional Information
Gene ID 81502
Other Names Minor histocompatibility antigen H13, 3423-, Intramembrane protease 1, IMP-1, IMPAS-1, hIMP1, Presenilin-like protein 3, Signal peptide peptidase, HM13, H13, IMP1, PSL3, SPP
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name HM13
Synonyms H13, IMP1, PSL3, SPP
Function Catalyzes intramembrane proteolysis of some signal peptides after they have been cleaved from a preprotein, resulting in the release of the fragment from the ER membrane into the cytoplasm. Required to generate lymphocyte cell surface (HLA-E) epitopes derived from MHC class I signal peptides (PubMed:11714810). May be necessary for the removal of the signal peptide that remains attached to the hepatitis C virus core protein after the initial proteolytic processing of the polyprotein (PubMed:12145199). Involved in the intramembrane cleavage of the integral membrane protein PSEN1 (PubMed:12077416, PubMed:11714810, PubMed:14741365). Cleaves the integral membrane protein XBP1 isoform 1 in a DERL1/RNF139-dependent manner (PubMed:25239945). May play a role in graft rejection (By similarity).
Cellular Location Endoplasmic reticulum membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein; Lumenal side
Tissue Location Widely expressed with highest levels in kidney, liver, placenta, lung, leukocytes and small intestine and reduced expression in heart and skeletal muscle. Expressed abundantly in the CNS with highest levels in thalamus and medulla
Research Areas
Citations (0)

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The protein encoded by this gene, which localizes to theendoplasmic reticulum, catalyzes intramembrane proteolysis of somesignal peptides after they have been cleaved from a preprotein.This activity is required to generate signal sequence-derived humanlymphocyte antigen-E epitopes that are recognized by the immunesystem, and to process hepatitis C virus core protein. The encodedprotein is an integral membrane protein with sequence motifscharacteristic of the presenilin-type aspartic proteases. Multipletranscript variants encoding several different isoforms have beenfound for this gene.


Sato, T., et al. Biochemistry 45(28):8649-8656(2006)Loureiro, J., et al. Nature 441(7095):894-897(2006)Urny, J., et al. Biochim. Biophys. Acta 1759 (3-4), 159-165 (2006) :Friedmann, E., et al. J. Biol. Chem. 279(49):50790-50798(2004)Soares, M.R., et al. FEBS Lett. 560 (1-3), 134-140 (2004) :

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$ 80.00
Cat# BP14392b
Availability: In Stock
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