|Other Names||ADP-ribosylation factor-like protein 4A, ARL4A, ARL4|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). GTP-binding protein that does not act as an allosteric activator of the cholera toxin catalytic subunit. Recruits CYTH1, CYTH2, CYTH3 and CYTH4 to the plasma membrane in GDP-bound form.|
|Cellular Location||Cell membrane. Cytoplasm. Nucleus, nucleolus. Note=Localization in the nucleolus is dependent by nucleotide binding|
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Provided below are standard protocols that you may find useful for product applications.
ADP-ribosylation factor-like 4A is a member of theADP-ribosylation factor family of GTP-binding proteins. ARL4A issimilar to ARL4C and ARL4D and each has a nuclear localizationsignal and an unusually high guaninine nucleotide exchange rate.ARL4A is located in both the nuclear and extranuclear cellcompartments. Multiple transcript variants encoding the sameprotein have been found for this gene.
Chi, J.H., et al. J. Neurosurg. 108(2):299-303(2008)Hofmann, I., et al. Curr. Biol. 17(8):711-716(2007)Lin, C.Y., et al. J. Biol. Chem. 275(48):37815-37823(2000)Suzuki, Y., et al. Genomics 64(3):286-297(2000)Jacobs, S., et al. FEBS Lett. 456(3):384-388(1999)
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