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NANOS1 Antibody (Center) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession Q8WY41
Clone Names 100525032
Additional Information
Gene ID 340719
Other Names Nanos homolog 1, NOS-1, EC_Rep1a, NANOS1, NOS1
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name NANOS1
Synonyms NOS1
Function May act as a translational repressor which regulates translation of specific mRNAs by forming a complex with PUM2 that associates with the 3'-UTR of mRNA targets. Capable of interfering with the proadhesive and anti-invasive functions of E-cadherin. Up-regulates the production of MMP14 to promote tumor cell invasion.
Cellular Location Cytoplasm, perinuclear region. Cytoplasm Note=Colocalizes with SNAPIN and PUM2 in the perinuclear region of germ cells.
Tissue Location Testis and ovary (at protein level). Predominantly expressed in testis. Specifically expressed during germline development. In adult tissues, it is mainly expressed in spermatogonia, the stem cells of the germline. Also expressed during meiosis in spermatocytes. Not present in late, post-meiotic stage germ cells Expressed in fetal ovaries, while it is weakly or not expressed in mature postmeiotic oocytes, suggesting that it may be expressed in premeiotic female germ cells. Expressed at high levels only in the E- cadherin deficient cell lines. Highly expressed in lung carcinomas and mostly detected in invasive tumor cells and its expression correlates with tumor aggressiveness.
Research Areas
Citations (0)
citation

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Background

NANOS1 may regulate translation of specific mRNAs by forming a complex with PUM2 that associates with the 3'-UTR of mRNA targets.

References

Ginter-Matuszewska, B., et al. Mol. Hum. Reprod. 15(3):173-179(2009)Bonnomet, A., et al. Oncogene 27(26):3692-3699(2008)Strumane, K., et al. Cancer Res. 66(20):10007-10015(2006)Kurokawa, H., et al. Dev. Growth Differ. 48(3):209-221(2006)Deloukas, P., et al. Nature 429(6990):375-381(2004)

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$ 277.78
Cat# BP14401c
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