|Other Names||Desmoglein-2, Cadherin family member 5, HDGC, DSG2, CDHF5|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.|
|Cellular Location||Cell membrane; Single-pass type I membrane protein. Cell junction, desmosome|
|Tissue Location||All of the tissues tested and carcinomas.|
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Desmosomes are cell-cell junctions between epithelial,myocardial, and certain other cell types. This gene product is acalcium-binding transmembrane glycoprotein component of desmosomesin vertebrate epithelial cells. Currently, three desmogleinsubfamily members have been identified and all are members of thecadherin cell adhesion molecule superfamily. These desmoglein genefamily members are located in a cluster on chromosome 18. Thissecond family member is expressed in colon, colon carcinoma, andother simple and stratified epithelial-derived cell lines.Mutations in this gene have been associated with arrhythmogenicright ventricular dysplasia, familial, 10.
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Fressart, V., et al. Europace 12(6):861-868(2010)Schlegel, N., et al. Am. J. Physiol. Gastrointest. Liver Physiol. 298 (5), G774-G783 (2010) :Cox, M.G., et al. Circ Arrhythm Electrophysiol 3(2):126-133(2010)Buxens, A., et al. Scand J Med Sci Sports (2010) In press :
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