|Other Names||Receptor-type tyrosine-protein phosphatase epsilon, Protein-tyrosine phosphatase epsilon, R-PTP-epsilon, PTPRE|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Isoform 1 plays a critical role in signaling transduction pathways and phosphoprotein network topology in red blood cells. May play a role in osteoclast formation and function (By similarity).|
|Cellular Location||Isoform 1: Cell membrane; Single-pass type I membrane protein Isoform 3: Cytoplasm.|
|Tissue Location||Expressed in giant cell tumor (osteoclastoma rich in multinucleated osteoclastic cells)|
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The protein encoded by this gene is a member of theprotein tyrosine phosphatase (PTP) family. PTPs are known to besignaling molecules that regulate a variety of cellular processesincluding cell growth, differentiation, mitotic cycle, andoncogenic transformation. Two alternatively spliced transcriptvariants of this gene have been reported, one of which encodes areceptor-type PTP that possesses a short extracellular domain, asingle transmembrane region, and two tandem intracytoplasmiccatalytic domains; Another one encodes a PTP that contains adistinct hydrophilic N-terminus, and thus represents anonreceptor-type isoform of this PTP. Studies of the similar genein mice suggested the regulatory roles of this PTP in RAS relatedsignal transduction pathways, cytokines induced SATA signaling, aswell as the activation of voltage-gated K+ channels. [provided byRefSeq].
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Joslyn, G., et al. Alcohol. Clin. Exp. Res. 34(5):800-812(2010)Barr, A.J., et al. Cell 136(2):352-363(2009)Kraut-Cohen, J., et al. J. Biol. Chem. 283(8):4612-4621(2008)Tremblay, K., et al. PLoS ONE 3 (8), E2907 (2008) :
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