|Other Names||Sphingosine 1-phosphate receptor 5, S1P receptor 5, S1P5, Endothelial differentiation G-protein-coupled receptor 8, Sphingosine 1-phosphate receptor Edg-8, S1P receptor Edg-8, S1PR5, EDG8|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Receptor for the lysosphingolipid sphingosine 1- phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. Is coupled to both the G(i/0)alpha and G(12) subclass of heteromeric G-proteins (By similarity). May play a regulatory role in the transformation of radial glial cells into astrocytes and may affect proliferative activity of these cells.|
|Cellular Location||Cell membrane; Multi-pass membrane protein.|
|Tissue Location||Widely expressed in the brain, most prominently in the corpus callosum, which is predominantly white matter. Detected in spleen, peripheral blood leukocytes, placenta, lung, aorta and fetal spleen. Low-level signal detected in many tissue extracts. Overexpressed in leukemic large granular lymphocytes. Isoform 1 is predominantly expressed in peripheral tissues. Isoform 2 is expressed in brain, spleen and peripheral blood leukocytes.|
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The lysosphingolipid sphingosine 1-phosphate (S1P)regulates cell proliferation, apoptosis, motility, and neuriteretraction. Its actions may be both intracellular as a secondmessenger and extracellular as a receptor ligand. S1P and thestructurally related lysolipid mediator lysophosphatidic acid (LPA)signal cells through a set of G protein-coupled receptors known asEDG receptors. Some EDG receptors (e.g., EDG1; MIM 601974) are S1Preceptors; others (e.g., EDG2; MIM 602282) are LPAreceptors.
Chang, C.L., et al. Am. J. Physiol., Cell Physiol. 297 (2), C451-C458 (2009) :Gillies, L., et al. Cell. Signal. 21(5):675-684(2009)Miron, V.E., et al. Ann. Neurol. 63(1):61-71(2008)Ulfig, N., et al. Acta Histochem. 106(5):373-378(2004)Vogler, R., et al. J. Invest. Dermatol. 120(4):693-700(2003)
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