|Other Names||Zinc finger protein ZIC 4, Zinc finger protein of the cerebellum 4, ZIC4|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Binds to DNA.|
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This gene encodes a member of the ZIC family of C2H2-typezinc finger proteins. Members of this family are important duringdevelopment, and have been associated with X-linked visceralheterotaxy and holoprosencephaly type 5. This gene is closelylinked to the gene encoding zinc finger protein of the cerebellum1, a related family member on chromosome 3. Heterozygous deletionof these linked genes is involved in Dandy-Walker malformation,which is a congenital cerebellar malformation. Multiple transcriptvariants have been identified for this gene.
Grinberg, I., et al. Clin. Genet. 67(4):290-296(2005)Jaster, J.H. Neurology 63 (7), 1339 (2004) :Grinberg, I., et al. Nat. Genet. 36(10):1053-1055(2004)Ohtsuka, M., et al. Genomics 83(6):1063-1071(2004)Bataller, L., et al. Neurology 62(5):778-782(2004)
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