|Other Names||Transcription factor Sp3, SPR-2, SP3|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Transcriptional factor that can act as an activator or repressor depending on isoform and/or post-translational modifications. Binds to GT and GC boxes promoter elements. Competes with SP1 for the GC-box promoters. Weak activator of transcription but can activate a number of genes involved in different processes such as cell-cycle regulation, hormone- induction and house-keeping.|
|Cellular Location||Nucleus. Nucleus, PML body. Note=Localizes to the nuclear periphery and in nuclear dots when sumoylated. Some localization in PML nuclear bodies|
|Tissue Location||Ubiquitously expressed.|
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This gene belongs to a family of Sp1 related genes thatencode transcription factors that regulate transcription by bindingto consensus GC- and GT-box regulatory elements in target genes.This protein contains a zinc finger DNA-binding domain and severaltransactivation domains, and has been reported to function as abifunctional transcription factor that either stimulates orrepresses the transcription of numerous genes. Transcript variantsencoding different isoforms have been described for this gene, andone has been reported to initiate translation from a non-AUG (AUA)start codon. Additional isoforms, resulting from the use ofalternate downstream translation initiation sites, have also beennoted. A related pseudogene has been identified on chromosome 13.
Yamaguchi, K., et al. Biochem. J. 430(1):107-117(2010)Jutooru, I., et al. J. Biol. Chem. 285(33):25332-25344(2010)Markovics, J.A., et al. J. Biol. Chem. 285(32):24695-24706(2010)Eckerstorfer, P., et al. Mol. Immunol. 47 (11-12), 2094-2102 (2010) :Moran, K.M., et al. Gene 341, 235-247 (2004) :
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