Foundational characteristics of cancer include proliferation, angiogenesis, migration, evasion of apoptosis, and cellular immortality. Find key markers for these cellular processes and antibodies to detect them.
The SUMOplot™ Analysis Program predicts and scores sumoylation sites in your protein. SUMOylation is a post-translational modification involved in various cellular processes, such as nuclear-cytosolic transport, transcriptional regulation, apoptosis, protein stability, response to stress, and progression through the cell cycle.
The Autophagy Receptor Motif Plotter predicts and scores autophagy receptor binding sites in your protein. Identifying proteins connected to this pathway is critical to understanding the role of autophagy in physiological as well as pathological processes such as development, differentiation, neurodegenerative diseases, stress, infection, and cancer.
KPNA1 Antibody (N-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P52294 |
|---|---|
| Clone Names | 100525097 |
| Gene ID | 3836 |
|---|---|
| Other Names | Importin subunit alpha-5, Karyopherin subunit alpha-1, Nucleoprotein interactor 1, NPI-1, RAG cohort protein 2, SRP1-beta, Importin subunit alpha-5, N-terminally processed, KPNA1, RCH2 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | KPNA1 |
|---|---|
| Synonyms | RCH2 |
| Function | Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1 (PubMed:7892216, PubMed:8692858, PubMed:27713473). Binds specifically and directly to substrates containing either a simple or bipartite NLS motif (PubMed:7892216, PubMed:8692858, PubMed:27713473). Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism (PubMed:7892216, PubMed:27713473). At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin (PubMed:7892216). The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (PubMed:7892216). |
| Cellular Location | Cytoplasm. Nucleus |
| Tissue Location | Expressed ubiquitously. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Background
Recombination activating proteins RAG1 and RAG2 regulateand mediate V(D)J recombination, the process by which genes forimmunoglobulins and T-cell receptors are generated. Several otherubiquitously expressed proteins are thought to be recruited in therecombination process. Among these are the genes affected in severecombined immune deficiency and genes involved in ds-DNA breakrepair. The protein encoded by this gene interacts with RAG1 andmay play a role in V(D)J recombination. Two transcript variants,one protein-coding and the other not, have been found for thisgene.
References
O'Seaghdha, C.M., et al. Hum. Mol. Genet. 19(21):4296-4303(2010)Yang, S.N., et al. J. Biol. Chem. 285(26):19935-19946(2010)Bian, X.L., et al. Virus Res. 150 (1-2), 135-137 (2010) :Mateo, M., et al. J. Virol. 84(2):1169-1175(2010)Simkus, C., et al. Mol. Immunol. 46(7):1319-1325(2009)
If you have used an Abcepta product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at tech@abcepta.com.
Ordering Information
Other Products
Shipping Information
