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KPNA1 Antibody (N-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession P52294
Clone Names 100525097
Peptide ID 100525097
Additional Information
Gene ID 3836
Other Names Importin subunit alpha-5, Karyopherin subunit alpha-1, Nucleoprotein interactor 1, NPI-1, RAG cohort protein 2, SRP1-beta, Importin subunit alpha-5, N-terminally processed, KPNA1, RCH2
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name KPNA1
Synonyms RCH2
Function Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non- classical NLS.
Cellular Location Cytoplasm. Nucleus
Tissue Location Expressed ubiquitously.
Research Areas
Citations (0)

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Recombination activating proteins RAG1 and RAG2 regulateand mediate V(D)J recombination, the process by which genes forimmunoglobulins and T-cell receptors are generated. Several otherubiquitously expressed proteins are thought to be recruited in therecombination process. Among these are the genes affected in severecombined immune deficiency and genes involved in ds-DNA breakrepair. The protein encoded by this gene interacts with RAG1 andmay play a role in V(D)J recombination. Two transcript variants,one protein-coding and the other not, have been found for thisgene.


O'Seaghdha, C.M., et al. Hum. Mol. Genet. 19(21):4296-4303(2010)Yang, S.N., et al. J. Biol. Chem. 285(26):19935-19946(2010)Bian, X.L., et al. Virus Res. 150 (1-2), 135-137 (2010) :Mateo, M., et al. J. Virol. 84(2):1169-1175(2010)Simkus, C., et al. Mol. Immunol. 46(7):1319-1325(2009)

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$ 80.00
Cat# BP14416a
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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