|Other Names||DNA-directed RNA polymerases I, II, and III subunit RPABC1, RNA polymerases I, II, and III subunit ABC1, DNA-directed RNA polymerase II 23 kDa polypeptide, DNA-directed RNA polymerase II subunit E, RPB5 homolog, XAP4, POLR2E|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, POLR2E/RPB5 is part of the lower jaw surrounding the central large cleft and thought to grab the incoming DNA template. Seems to be the major component in this process (By similarity).|
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This gene encodes the fifth largest subunit of RNApolymerase II, the polymerase responsible for synthesizingmessenger RNA in eukaryotes. This subunit is shared by the othertwo DNA-directed RNA polymerases and is present in two-fold molarexcess over the other polymerase subunits. An interaction betweenthis subunit and a hepatitis virus transactivating protein has beendemonstrated, suggesting that interaction between transcriptionalactivators and the polymerase can occur through this subunit. Apseudogene is located on chromosome 11.
Hosgood, H.D. III, et al. Occup Environ Med 66(12):848-853(2009)Cloutier, P., et al. Methods 48(4):381-386(2009)Michiels, S., et al. Carcinogenesis 30(5):763-768(2009)Lamesch, P., et al. Genomics 89(3):307-315(2007)Le, T.T., et al. J. Biochem. 138(3):215-224(2005)
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