|Other Names||Guanine nucleotide-binding protein G(i) subunit alpha-2, Adenylate cyclase-inhibiting G alpha protein, GNAI2, GNAI2B|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. May play a role in cell division.|
|Cellular Location||Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cell membrane. Membrane; Lipid- anchor. Note=Localizes in the centrosomes of interphase and mitotic cells. Detected at the cleavage furrow and/or the midbody|
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The protein encoded by this gene is an alpha subunit ofguanine nucleotide binding proteins (G proteins). The encodedprotein contains the guanine nucleotide binding site and isinvolved in the hormonal regulation of adenylate cyclase. Severaltranscript variants encoding different isoforms have been detectedfor this gene, but the full-length nature of only two are known sofar.
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)So, H.C., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 153B (1), 103-113 (2010) :Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)Kuszak, A.J., et al. J. Biol. Chem. 284(39):26732-26741(2009)Huang, X., et al. Med. Hypotheses 73(1):56-59(2009)
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