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CHRM2 Antibody (Center) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession P08172
Clone Names 100525107
Peptide ID 100525107
Additional Information
Gene ID 1129
Other Names Muscarinic acetylcholine receptor M2, CHRM2
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name CHRM2
Function The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is adenylate cyclase inhibition. Signaling promotes phospholipase C activity, leading to the release of inositol trisphosphate (IP3); this then triggers calcium ion release into the cytosol.
Cellular Location Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Note=Phosphorylation in response to agonist binding promotes receptor internalization.
Research Areas
Citations (0)

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The muscarinic cholinergic receptors belong to a largerfamily of G protein-coupled receptors. The functional diversity ofthese receptors is defined by the binding of acetylcholine to thesereceptors and includes cellular responses such as adenylate cyclaseinhibition, phosphoinositide degeneration, and potassium channelmediation. Muscarinic receptors influence many effects ofacetylcholine in the central and peripheral nervous system. Themuscarinic cholinergic receptor 2 is involved in mediation ofbradycardia and a decrease in cardiac contractility. Multiplealternatively spliced transcript variants have been described forthis gene.


Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Ruano, G., et al. Pharmacogenomics 11(7):959-971(2010)Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Cannon, D.M., et al. Mol. Psychiatry (2010) In press :Bosker, F.J., et al. Mol. Psychiatry (2010) In press :

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$ 80.00
Cat# BP14420c
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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