|Other Names||Sodium/iodide cotransporter, Na(+)/I(-) cotransporter, Sodium-iodide symporter, Na(+)/I(-) symporter, Solute carrier family 5 member 5, SLC5A5, NIS|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Mediates iodide uptake in the thyroid gland.|
|Cellular Location||Membrane; Multi-pass membrane protein.|
|Tissue Location||Expression is primarily in thyroid tissue, but also to a lower extent in mammary gland and ovary. Expression is reduced in tumors.|
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This gene encodes a member of the sodium glucosecotransporter family. The encoded protein is responsible for theuptake of iodine in tissues such as the thyroid and lactatingbreast tissue. The iodine taken up by the thyroid is incorporatedinto the metabolic regulators triiodothyronine (T3) andtetraiodothyronine (T4). Mutations in this gene are associated withthyroid dyshormonogenesis 1.
Spitzweg, C., et al. Mol. Cell. Endocrinol. 322 (1-2), 56-63 (2010) :Ricci, D., et al. Transplant. Proc. 42(5):1888-1894(2010)Renier, C., et al. J. Neurooncol. 96(3):331-336(2010)Montanelli, L., et al. Thyroid 19(12):1419-1425(2009)Smith, V.E., et al. J. Cell. Sci. 122 (PT 18), 3393-3402 (2009) :
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