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SLC5A5 Antibody (C-term) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession Q92911
Clone Names 100525117
Additional Information
Gene ID 6528
Other Names Sodium/iodide cotransporter, Na(+)/I(-) cotransporter, Sodium-iodide symporter, Na(+)/I(-) symporter, Solute carrier family 5 member 5, SLC5A5, NIS
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name SLC5A5
Synonyms NIS
Function Sodium:iodide symporter that mediates the transport of iodide into the thyroid gland (PubMed:8806637, PubMed:9329364, PubMed:20797386, PubMed:12488351, PubMed:18372236, PubMed:18708479, PubMed:31310151, PubMed:32084174). Can also mediate the transport of chlorate, thiocynate, nitrate and selenocynate (PubMed:12488351).
Cellular Location Cell membrane; Multi-pass membrane protein. Cytoplasm
Tissue Location Expression is primarily in thyroid tissue, but also to a lower extent in mammary gland and ovary. Expression is reduced in tumors.
Research Areas
Citations (0)
citation

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Background

This gene encodes a member of the sodium glucosecotransporter family. The encoded protein is responsible for theuptake of iodine in tissues such as the thyroid and lactatingbreast tissue. The iodine taken up by the thyroid is incorporatedinto the metabolic regulators triiodothyronine (T3) andtetraiodothyronine (T4). Mutations in this gene are associated withthyroid dyshormonogenesis 1.

References

Spitzweg, C., et al. Mol. Cell. Endocrinol. 322 (1-2), 56-63 (2010) :Ricci, D., et al. Transplant. Proc. 42(5):1888-1894(2010)Renier, C., et al. J. Neurooncol. 96(3):331-336(2010)Montanelli, L., et al. Thyroid 19(12):1419-1425(2009)Smith, V.E., et al. J. Cell. Sci. 122 (PT 18), 3393-3402 (2009) :

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$ 277.78
Cat# BP14422b
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