SLC5A5 Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q92911 |
---|---|
Clone Names | 100525117 |
Gene ID | 6528 |
---|---|
Other Names | Sodium/iodide cotransporter, Na(+)/I(-) cotransporter, Sodium-iodide symporter, Na(+)/I(-) symporter, Solute carrier family 5 member 5, SLC5A5, NIS |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | SLC5A5 |
---|---|
Synonyms | NIS |
Function | Sodium:iodide symporter that mediates the transport of iodide into the thyroid gland (PubMed:8806637, PubMed:9329364, PubMed:20797386, PubMed:12488351, PubMed:18372236, PubMed:18708479, PubMed:31310151, PubMed:32084174). Can also mediate the transport of chlorate, thiocynate, nitrate and selenocynate (PubMed:12488351). |
Cellular Location | Cell membrane; Multi-pass membrane protein. Cytoplasm |
Tissue Location | Expression is primarily in thyroid tissue, but also to a lower extent in mammary gland and ovary. Expression is reduced in tumors. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a member of the sodium glucosecotransporter family. The encoded protein is responsible for theuptake of iodine in tissues such as the thyroid and lactatingbreast tissue. The iodine taken up by the thyroid is incorporatedinto the metabolic regulators triiodothyronine (T3) andtetraiodothyronine (T4). Mutations in this gene are associated withthyroid dyshormonogenesis 1.
References
Spitzweg, C., et al. Mol. Cell. Endocrinol. 322 (1-2), 56-63 (2010) :Ricci, D., et al. Transplant. Proc. 42(5):1888-1894(2010)Renier, C., et al. J. Neurooncol. 96(3):331-336(2010)Montanelli, L., et al. Thyroid 19(12):1419-1425(2009)Smith, V.E., et al. J. Cell. Sci. 122 (PT 18), 3393-3402 (2009) :
If you have used an Abcepta product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at tech@abcepta.com.