|Other Names||Adenosine receptor A1, ADORA1|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase.|
|Cellular Location||Cell membrane; Multi-pass membrane protein.|
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The protein encoded by this gene is an adenosine receptorthat belongs to the G-protein coupled receptor 1 family. There are3 types of adenosine receptors, each with a specific pattern ofligand binding and tissue distribution, and together they regulatea diverse set of physiologic functions. The type A1 receptorsinhibit adenylyl cyclase, and play a role in the fertilizationprocess. Animal studies also suggest a role for A1 receptors inkidney function and ethanol intoxication. Transcript variants withalternative splicing in the 5' UTR have been found for this gene.
Lane, J.R., et al. Biochem. Pharmacol. 80(8):1180-1189(2010)Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Wagner, A.K., et al. Epilepsy Res. 90(3):259-272(2010)Ruano, G., et al. Pharmacogenomics 11(7):959-971(2010)Pinheiro, A.P., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 153B (5), 1070-1080 (2010) :
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