|Other Names||Histamine H1 receptor, H1R, HH1R, HRH1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||In peripheral tissues, the H1 subclass of histamine receptors mediates the contraction of smooth muscles, increase in capillary permeability due to contraction of terminal venules, and catecholamine release from adrenal medulla, as well as mediating neurotransmission in the central nervous system.|
|Cellular Location||Cell membrane; Multi-pass membrane protein|
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Histamine is a ubiquitous messenger molecule released frommast cells, enterochromaffin-like cells, and neurons. Its variousactions are mediated by histamine receptors H1, H2, H3 and H4. Thisgene was thought to be intronless until recently. The proteinencoded by this gene is an integral membrane protein and belongs tothe G protein-coupled receptor superfamily. It mediates thecontraction of smooth muscles, the increase in capillarypermeability due to contraction of terminal venules, the release ofcatecholamine from adrenal medulla, and neurotransmission in thecentral nervous system. Multiple alternatively spliced variants,encoding the same protein, have been identified. [provided byRefSeq].
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Ruano, G., et al. Pharmacogenomics 11(7):959-971(2010)Davila, S., et al. Genes Immun. 11(3):232-238(2010)Notcovich, C., et al. Exp. Cell Res. 316(3):401-411(2010)Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
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