|Other Names||Glutamate receptor ionotropic, kainate 2, GluK2, Excitatory amino acid receptor 4, EAA4, Glutamate receptor 6, GluR-6, GluR6, GRIK2, GLUR6|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L- glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. May be involved in the transmission of light information from the retina to the hypothalamus. Modulates cell surface expression of NETO2 (By similarity).|
|Cellular Location||Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein|
|Tissue Location||Expression is higher in cerebellum than in cerebral cortex|
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Glutamate receptors are the predominant excitatoryneurotransmitter receptors in the mammalian brain and are activatedin a variety of normal neurophysiologic processes. This geneproduct belongs to the kainate family of glutamate receptors, whichare composed of four subunits and function as ligand-activated ionchannels. The subunit encoded by this gene is subject to RNAediting at multiple sites within the first and second transmembranedomains, which is thought to alter the structure and function ofthe receptor complex. Alternatively spliced transcript variantsencoding different isoforms have also been described for this gene.Mutations in this gene have been associated with autosomalrecessive mental retardation.
Han, Y., et al. Biochemistry 49(43):9207-9216(2010)Holt, R., et al. Eur. J. Hum. Genet. 18(9):1013-1019(2010)Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Sampaio, A.S., et al. CNS Neurosci Ther (2010) In press :Sander, T., et al. Neurology 45(9):1713-1720(1995)
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