Foundational characteristics of cancer include proliferation, angiogenesis, migration, evasion of apoptosis, and cellular immortality. Find key markers for these cellular processes and antibodies to detect them.
The SUMOplot™ Analysis Program predicts and scores sumoylation sites in your protein. SUMOylation is a post-translational modification involved in various cellular processes, such as nuclear-cytosolic transport, transcriptional regulation, apoptosis, protein stability, response to stress, and progression through the cell cycle.
The Autophagy Receptor Motif Plotter predicts and scores autophagy receptor binding sites in your protein. Identifying proteins connected to this pathway is critical to understanding the role of autophagy in physiological as well as pathological processes such as development, differentiation, neurodegenerative diseases, stress, infection, and cancer.
GRIK2 Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q13002 |
|---|---|
| Clone Names | 100525146 |
| Gene ID | 2898 |
|---|---|
| Other Names | Glutamate receptor ionotropic, kainate 2, GluK2, Excitatory amino acid receptor 4, EAA4, Glutamate receptor 6, GluR-6, GluR6, GRIK2, GLUR6 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | GRIK2 |
|---|---|
| Synonyms | GLUR6 |
| Function | Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist (PubMed:28180184). Modulates cell surface expression of NETO2 (By similarity). |
| Cellular Location | Cell membrane; Multi-pass membrane protein. Postsynaptic cell membrane; Multi-pass membrane protein |
| Tissue Location | Expression is higher in cerebellum than in cerebral cortex |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Background
Glutamate receptors are the predominant excitatoryneurotransmitter receptors in the mammalian brain and are activatedin a variety of normal neurophysiologic processes. This geneproduct belongs to the kainate family of glutamate receptors, whichare composed of four subunits and function as ligand-activated ionchannels. The subunit encoded by this gene is subject to RNAediting at multiple sites within the first and second transmembranedomains, which is thought to alter the structure and function ofthe receptor complex. Alternatively spliced transcript variantsencoding different isoforms have also been described for this gene.Mutations in this gene have been associated with autosomalrecessive mental retardation.
References
Han, Y., et al. Biochemistry 49(43):9207-9216(2010)Holt, R., et al. Eur. J. Hum. Genet. 18(9):1013-1019(2010)Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Sampaio, A.S., et al. CNS Neurosci Ther (2010) In press :Sander, T., et al. Neurology 45(9):1713-1720(1995)
If you have used an Abcepta product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at tech@abcepta.com.
Ordering Information
Other Products
Shipping Information
