HNMT Blocking Peptide (N-term)
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | P50135 |
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Gene ID | 3176 |
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Other Names | Histamine N-methyltransferase, HMT, HNMT |
Target/Specificity | The synthetic peptide sequence is selected from aa 44-58 of HUMAN HNMT |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | HNMT |
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Function | Inactivates histamine by N-methylation. Plays an important role in degrading histamine and in regulating the airway response to histamine. |
Cellular Location | Cytoplasm. |
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Provided below are standard protocols that you may find useful for product applications.
Background
In mammals, histamine is metabolized by two major pathways: N(tau)-methylation via histamine N-methyltransferase and oxidative deamination via diamine oxidase. HNMT is the first enzyme which is found in the cytosol and uses S-adenosyl-L-methionine as the methyl donor. In the mammalian brain, the neurotransmitter activity of histamine is controlled by N(tau)-methylation as diamine oxidase is not found in the central nervous system. A common genetic polymorphism affects the activity levels of this gene product in red blood cells.
References
Aksoy, S., et al., Biochem. Biophys. Res. Commun. 219(2):548-554 (1996).
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