|Other Names||Serine/threonine-protein kinase pim-3, Pim3|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Proto-oncogene with serine/threonine kinase activity that can prevent apoptosis and promote cell survival and protein translation. May contribute to tumorigenesis through: the delivery of survival signaling through phosphorylation of BAD which induces release of the anti-apoptotic protein Bcl-X(L), the regulation of cell cycle progression and protein synthesis and by regulation of MYC transcriptional activity. Additionally to this role on tumorigenesis, can also negatively regulate insulin secretion by inhibiting the activation of MAPK1/3 (ERK1/2), through SOCS6. Involved also in the control of energy metabolism and regulation of AMPK activity in modulating MYC and PPARGC1A protein levels and cell growth.|
|Tissue Location||Detected in pancreas but exclusively in beta- cells.|
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Able to phosphorylate CDKN1B in vitro. Involved in cell cycle progression and suppression of apoptosis (By similarity).
Lin, Y.W., et al. Blood 115(4):824-833(2010)Zhang, P., et al. J. Cell. Physiol. 220(1):82-90(2009)Wood, N.T., et al. FEBS Lett. 583(4):615-620(2009)Chen, J.L., et al. Blood 111(3):1677-1685(2008)Aksoy, I., et al. Stem Cells 25(12):2996-3004(2007)
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