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>   home   >   Products   >   Peptides   >   Blocking Peptides   >   Mouse Mapk9 Antibody (Center) Blocking Peptide   

Mouse Mapk9 Antibody (Center) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q9WTU6
Clone Names 110316255
Peptide ID 110316255
Additional Information
Gene ID 26420
Other Names Mitogen-activated protein kinase 9, MAP kinase 9, MAPK 9, Stress-activated protein kinase JNK2, c-Jun N-terminal kinase 2, Mapk9, Jnk2, Prkm9
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name Mapk9
Synonyms Jnk2, Prkm9
Function Serine/threonine-protein kinase involved in various processes such as cell proliferation, differentiation, migration, transformation and programmed cell death. Extracellular stimuli such as proinflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK9/JNK2. In turn, MAPK9/JNK2 phosphorylates a number of transcription factors, primarily components of AP-1 such as JUN and ATF2 and thus regulates AP-1 transcriptional activity. In response to oxidative or ribotoxic stresses, inhibits rRNA synthesis by phosphorylating and inactivating the RNA polymerase 1-specific transcription initiation factor RRN3. Promotes stressed cell apoptosis by phosphorylating key regulatory factors including TP53 and YAP1. In T-cells, MAPK8 and MAPK9 are required for polarized differentiation of T-helper cells into Th1 cells. Upon T-cell receptor (TCR) stimulation, is activated by CARMA1, BCL10, MAP2K7 and MAP3K7/TAK1 to regulate JUN protein levels. Plays an important role in the osmotic stress-induced epithelial tight-junctions disruption. When activated, promotes beta-catenin/CTNNB1 degradation and inhibits the canonical Wnt signaling pathway. Participates also in neurite growth in spiral ganglion neurons. Phosphorylates the CLOCK-ARNTL/BMAL1 heterodimer and plays a role in the regulation of the circadian clock (PubMed:22441692).
Cellular Location Cytoplasm. Nucleus
Tissue Location All four isoforms are widely distributed in brain. Isoforms alpha-1 and alpha-2 are predominantly expressed in hippocampus, cerebral cortex, caudate-putamen, amygdala and the granule layer of the cerebellum. Alpha-1 is more abundant than alpha-2 in the periaqueductal region and the substantia nigra
Research Areas
Citations (0)

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Mapk9 responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, primarily components of AP-1 such as c-Jun and ATF2 and thus regulates AP-1 transcriptional activity. In T-cells, JNK1 and JNK2 are required for polarized differentiation of T-helper cells into Th1 cells.


Sherrin, T., et al. J. Neurosci. 30(40):13348-13361(2010)Yeap, Y.Y., et al. Biochem. J. 430(2):345-354(2010)Samak, G., et al. Am. J. Physiol. Gastrointest. Liver Physiol. 299 (3), G572-G584 (2010) :Cao, Y., et al. Immunol. Lett. 132 (1-2), 38-44 (2010) :Cellurale, C., et al. PLoS ONE 5 (8), E12469 (2010) :

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$ 80.00
Cat# BP14446c
(40 western blots)
Availability: In Stock
Bulk Size
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