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Mouse Prkaca/Prkacb Antibody (C-term) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession P68181
Clone Names 110316345
Peptide ID 110316345
Additional Information
Gene ID 18749
Other Names cAMP-dependent protein kinase catalytic subunit beta, PKA C-beta, Prkacb, Pkacb
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name Prkacb
Synonyms Pkacb
Function Mediates cAMP-dependent signaling triggered by receptor binding to GPCRs. PKA activation regulates diverse cellular processes such as cell proliferation, the cell cycle, differentiation and regulation of microtubule dynamics, chromatin condensation and decondensation, nuclear envelope disassembly and reassembly, as well as regulation of intracellular transport mechanisms and ion flux. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis (By similarity).
Cellular Location Cytoplasm. Cell membrane. Membrane {ECO:0000250|UniProtKB:P22694}; Lipid- anchor {ECO:0000250|UniProtKB:P22694}. Nucleus Note=Translocates into the nucleus (monomeric catalytic subunit) The inactive holoenzyme is found in the cytoplasm.
Tissue Location Isoform 1 is found in all tissues examined, with the highest expression in the brain and very low levels in the testis. Isoform 2 is strongly expressed in the brain, in the prelimbic and insular cortex. Isoform 3 is also found only in the brain, but at very low levels.
Research Areas
Citations (0)

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Background

Mediates cAMP-dependent signaling triggered by receptor binding to GPCRs. PKA activation regulates diverse cellular processes such as cell proliferation, the cell cycle, differentiation and regulation of microtubule dynamics, chromatin condensation and decondensation, nuclear envelope disassembly and reassembly, as well as regulation of intracellular transport mechanisms and ion flux.

References

Ribeiro, R.A., et al. Br. J. Nutr. 104(8):1148-1155(2010)Liu, J.X., et al. Seizure 19(7):414-420(2010)Ha, C.H., et al. Proc. Natl. Acad. Sci. U.S.A. 107(35):15467-15472(2010)Sarma, S., et al. Proc. Natl. Acad. Sci. U.S.A. 107(29):13165-13170(2010)Rah, S.Y., et al. J. Biol. Chem. 285(28):21877-21887(2010)

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$ 80.00
Cat# BP14456b
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