|Other Names||Mitogen-activated protein kinase kinase kinase kinase 4, HPK/GCK-like kinase HGK, MAPK/ERK kinase kinase kinase 4, MEK kinase kinase 4, MEKKK 4, Nck-interacting kinase, Map4k4, Nik|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Serine/threonine kinase that may play a role in the response to environmental stress and cytokines such as TNF-alpha. Appears to act upstream of the JUN N-terminal pathway. Phosphorylates SMAD1 on Thr-322 (By similarity).|
|Tissue Location||Appears to be ubiquitous, expressed in all tissue types examined. Highest levels observed in heart and brain|
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Provided below are standard protocols that you may find useful for product applications.
Serine/threonine kinase that may play a role in the response to environmental stress and cytokines such as TNF-alpha. Appears to act upstream of the JUN N-terminal pathway.
Maruyama, T., et al. J. Bone Miner. Res. 25(5):1058-1067(2010)Guntur, K.V., et al. J. Biol. Chem. 285(9):6595-6603(2010)Aouadi, M., et al. Nature 458(7242):1180-1184(2009)Wittwer, T., et al. Biochem. Biophys. Res. Commun. 371(2):294-297(2008)Tesz, G.J., et al. J. Biol. Chem. 282(27):19302-19312(2007)
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