Mouse Map4k4 Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | P97820 |
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Clone Names | 110316241 |
Gene ID | 26921 |
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Other Names | Mitogen-activated protein kinase kinase kinase kinase 4, HPK/GCK-like kinase HGK, MAPK/ERK kinase kinase kinase 4, MEK kinase kinase 4, MEKKK 4, Nck-interacting kinase, Map4k4, Nik |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | Map4k4 |
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Synonyms | Nik |
Function | Serine/threonine kinase that may play a role in the response to environmental stress and cytokines such as TNF-alpha. Appears to act upstream of the JUN N-terminal pathway. Phosphorylates SMAD1 on Thr-322 (By similarity). |
Cellular Location | Cytoplasm. |
Tissue Location | Appears to be ubiquitous, expressed in all tissue types examined. Highest levels observed in heart and brain |
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Provided below are standard protocols that you may find useful for product applications.
Background
Serine/threonine kinase that may play a role in the response to environmental stress and cytokines such as TNF-alpha. Appears to act upstream of the JUN N-terminal pathway.
References
Maruyama, T., et al. J. Bone Miner. Res. 25(5):1058-1067(2010)Guntur, K.V., et al. J. Biol. Chem. 285(9):6595-6603(2010)Aouadi, M., et al. Nature 458(7242):1180-1184(2009)Wittwer, T., et al. Biochem. Biophys. Res. Commun. 371(2):294-297(2008)Tesz, G.J., et al. J. Biol. Chem. 282(27):19302-19312(2007)
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