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OTUB2 Antibody (N-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q96DC9 |
|---|---|
| Clone Names | 110330007 |
| Gene ID | 78990 |
|---|---|
| Other Names | Ubiquitin thioesterase OTUB2, Deubiquitinating enzyme OTUB2, OTU domain-containing ubiquitin aldehyde-binding protein 2, Otubain-2, Ubiquitin-specific-processing protease OTUB2, OTUB2, C14orf137, OTB2, OTU2 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | OTUB2 |
|---|---|
| Synonyms | C14orf137, OTB2, OTU2 |
| Function | Hydrolase that can remove conjugated ubiquitin from proteins in vitro and may therefore play an important regulatory role at the level of protein turnover by preventing degradation. Mediates deubiquitination of 'Lys-11'-,'Lys-48'- and 'Lys-63'-linked polyubiquitin chains, with a preference for 'Lys-63'-linked polyubiquitin chains. |
| Tissue Location | Widely expressed. Expressed at higher level in brain. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Otubains are deubiquitylating cysteine proteases (DUBs;see MIM 602519) that belong to the ovarian tumor (OTU) proteinsuperfamily. Like other DUBs, otubains cleave proteins precisely atthe ubiquitin (UB; see MIM 191339)-protein bond.
References
Li, S., et al. J. Biol. Chem. 285(7):4291-4297(2010)Sowa, M.E., et al. Cell 138(2):389-403(2009)Edelmann, M.J., et al. Biochem. J. 418(2):379-390(2009)Lamesch, P., et al. Genomics 89(3):307-315(2007)Nanao, M.H., et al. EMBO Rep. 5(8):783-788(2004)
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