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Mouse Wee2 Antibody (Center) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession Q66JT0
Clone Names 110328156
Peptide ID 110328156
Additional Information
Gene ID 381759
Other Names Wee1-like protein kinase 2, Wee1-like protein kinase 1B, Wee1B kinase, mWee1B, Wee2, Wee1b
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name Wee2
Synonyms Wee1b
Function Oocyte-specific protein tyrosine kinase that phosphorylates and inhibits CDK1 and acts as a key regulator of meiosis during both prophase I and metaphase II. Required to maintain meiotic arrest in oocytes during the germinal vesicle (GV) stage, a long period of quiescence at dictyate prophase I, by phosphorylating CDK1 at 'Tyr-15', leading to inhibit CDK1 activity and prevent meiotic reentry. Also required for metaphase II exit during egg activation by phosphorylating CDK1 at 'Tyr-15', to ensure exit from meiosis in oocytes and promote pronuclear formation.
Cellular Location Cytoplasm. Nucleus. Note=Localizes mainly in the nucleus. Exported from the nucleus to the cytoplasm before germinal vesicle breakdown (GVBD), allowing meiosis resumption
Tissue Location Ovary-specific..
Research Areas
Citations (0)

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Background

Phosphorylates and inhibits CDK1. May act as a negative regulator of entry into mitosis (G2 to M transition).

References

Oh, J.S., et al. J. Cell Biol. 188(2):199-207(2010)Joshi, S., et al. BMC Dev. Biol. 7, 67 (2007) :Han, S.J., et al. Curr. Biol. 15(18):1670-1676(2005)Nakanishi, M., et al. Genes Cells 5(10):839-847(2000)

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$ 80.00
Cat# BP14472c
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