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CD99 Antibody (N-term) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession P14209
Clone Names 100427019
Additional Information
Gene ID 4267
Other Names CD99 antigen, E2 antigen, Protein MIC2, T-cell surface glycoprotein E2, CD99, CD99, MIC2, MIC2X, MIC2Y
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name CD99
Synonyms MIC2, MIC2X, MIC2Y
Function Involved in T-cell adhesion processes and in spontaneous rosette formation with erythrocytes. Plays a role in a late step of leukocyte extravasation helping leukocytes to overcome the endothelial basement membrane. Acts at the same site as, but independently of, PECAM1. Involved in T-cell adhesion processes (By similarity).
Cellular Location Membrane; Single-pass type I membrane protein
Research Areas
Citations (0)
citation

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Background

The protein encoded by this gene is a cell surfaceglycoprotein involved in leukocyte migration, T-cell adhesion,ganglioside GM1 and transmembrane protein transport, and T-celldeath by a caspase-independent pathway. In addition, the encodedprotein may have the ability to rearrange the actin cytoskeletonand may also act as an oncosuppressor in osteosarcoma. CyclophilinA binds to CD99 and may act as a signaling regulator of CD99. Thisgene is found in the pseudoautosomal region of chromosomes X and Yand escapes X-chromosome inactivation. Two transcript variantsencoding different isoforms have been found for this gene.

References

Husak, Z., et al. J. Leukoc. Biol. 88(2):405-412(2010)Kanner, W.A., et al. J. Cutan. Pathol. 37(7):744-750(2010)Duncan, L.M., et al. J. Immunol. 184(12):6978-6985(2010)Rocchi, A., et al. J. Clin. Invest. 120(3):668-680(2010)Yoshino, N., et al. Ann Thorac Cardiovasc Surg 15(5):324-327(2009)

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$ 277.78
Cat# BP14489a
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