|Other Names||Chymotrypsin-like elastase family member 3A, Elastase IIIA, Elastase-3A, Protease E, CELA3A, ELA3, ELA3A|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Efficient protease with alanine specificity but only little elastolytic activity.|
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Provided below are standard protocols that you may find useful for product applications.
Elastases form a subfamily of serine proteases thathydrolyze many proteins in addition to elastin. Humans have sixelastase genes which encode the structurally similar proteinselastase 1, 2, 2A, 2B, 3A, and 3B. Unlike other elastases, elastase3A has little elastolytic activity. Like most of the humanelastases, elastase 3A is secreted from the pancreas as a zymogenand, like other serine proteases such as trypsin, chymotrypsin andkallikrein, it has a digestive function in the intestine. Elastase3A preferentially cleaves proteins after alanine residues. Elastase3A may also function in the intestinal transport and metabolism ofcholesterol. Both elastase 3A and elastase 3B have been referred toas protease E and as elastase 1.
Shimada, S., et al. Int. J. Mol. Med. 10(5):599-603(2002)Shirasu, Y., et al. J. Biochem. 104(2):259-264(1988)Tani, T., et al. J. Biol. Chem. 263(3):1231-1239(1988)
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