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ETV6 Antibody (Center) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession P41212
Clone Names 100430244
Additional Information
Gene ID 2120
Other Names Transcription factor ETV6, ETS translocation variant 6, ETS-related protein Tel1, Tel, ETV6, TEL, TEL1
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name ETV6
Synonyms TEL, TEL1
Function Transcriptional repressor; binds to the DNA sequence 5'- CCGGAAGT-3'. Plays a role in hematopoiesis and malignant transformation.
Cellular Location Nucleus.
Tissue Location Ubiquitous.
Research Areas
Citations (0)
citation

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Background

This gene encodes an ETS family transcription factor. Theproduct of this gene contains two functional domains: a N-terminalpointed (PNT) domain that is involved in protein-proteininteractions with itself and other proteins, and a C-terminalDNA-binding domain. Gene knockout studies in mice suggest that itis required for hematopoiesis and maintenance of the developingvascular network. This gene is known to be involved in a largenumber of chromosomal rearrangements associated with leukemia andcongenital fibrosarcoma.

References

Otsubo, K., et al. Cancer Genet. Cytogenet. 202(1):22-26(2010)Roukens, M.G., et al. Nat. Cell Biol. 12(10):933-942(2010)Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Gascon, E., et al. J. Neurosci. 30(37):12414-12423(2010)Liang, D.C., et al. Pediatr Blood Cancer 55(3):430-433(2010)

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$ 277.78
Cat# BP14496c
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Availability: 2 weeks
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