|Other Names||Transcription factor ETV6, ETS translocation variant 6, ETS-related protein Tel1, Tel, ETV6, TEL, TEL1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Transcriptional repressor; binds to the DNA sequence 5'- CCGGAAGT-3'. Plays a role in hematopoiesis and malignant transformation.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes an ETS family transcription factor. Theproduct of this gene contains two functional domains: a N-terminalpointed (PNT) domain that is involved in protein-proteininteractions with itself and other proteins, and a C-terminalDNA-binding domain. Gene knockout studies in mice suggest that itis required for hematopoiesis and maintenance of the developingvascular network. This gene is known to be involved in a largenumber of chromosomal rearrangements associated with leukemia andcongenital fibrosarcoma.
Otsubo, K., et al. Cancer Genet. Cytogenet. 202(1):22-26(2010)Roukens, M.G., et al. Nat. Cell Biol. 12(10):933-942(2010)Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Gascon, E., et al. J. Neurosci. 30(37):12414-12423(2010)Liang, D.C., et al. Pediatr Blood Cancer 55(3):430-433(2010)
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