|Other Names||SLAM family member 5, Cell surface antigen MAX3, Hly9-beta, Leukocyte differentiation antigen CD84, Signaling lymphocytic activation molecule 5, CD84, CD84, SLAMF5|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Plays a role as adhesion receptor functioning by homophilic interactions and by clustering. Recruits SH2 domain- containing proteins SH2D1A/SAP. Increases proliferative responses of activated T-cells and SH2D1A/SAP does not seen be required for this process. Homophilic interactions enhance interferon gamma/IFNG secretion in lymphocytes and induce platelet stimulation via a SH2D1A/SAP-dependent pathway. May serve as a marker for hematopoietic progenitor cells.|
|Cellular Location||Cell membrane; Single-pass type I membrane protein|
|Tissue Location||Predominantly expressed in hematopoietic tissues, such as lymph node, spleen and peripheral leukocytes Expressed in macrophages, B-cells, monocytes, platelets, thymocytes, T-cells and dendritic cells. Highly expressed in memory T-cells.|
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Provided below are standard protocols that you may find useful for product applications.
Members of the CD2 (see MIM 186990) subgroup of the Igsuperfamily, such as CD84, have similar patterns of conserveddisulfide bonds and function in adhesion interactions between Tlymphocytes and accessory cells.
Oliver-Vila, I., et al. Mol. Immunol. 45(8):2138-2149(2008)Yan, Q., et al. Proc. Natl. Acad. Sci. U.S.A. 104(25):10583-10588(2007)Nanda, N., et al. Blood 106(9):3028-3034(2005)Romero, X., et al. Tissue Antigens 64(2):132-144(2004)Zaiss, M., et al. Exp. Hematol. 31(9):798-805(2003)
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