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KLF1 Antibody (C-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q13351
Clone Names 100507008
Peptide ID 100507008
Additional Information
Gene ID 10661
Other Names Krueppel-like factor 1, Erythroid krueppel-like transcription factor, EKLF, KLF1, EKLF
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name KLF1
Synonyms EKLF
Function Transcription regulator of erythrocyte development that probably serves as a general switch factor during erythropoiesis. Is a dual regulator of fetal-to-adult globin switching. Binds to the CACCC box in the beta-globin gene promoter and acts as a preferential activator of this gene. Furthermore, it binds to the BCL11A promoter and activates expression of BCL11A, which in turn represses the HBG1 and HBG2 genes. This dual activity ensures that, in most adults, fetal hemoglobin levels are low. Able to activate CD44 and AQP1 promoters. When sumoylated, acts as a transcriptional repressor by promoting interaction with CDH2/MI2beta and also represses megakaryocytic differentiation.
Cellular Location Nucleus. Note=Colocalizes with SUMO1 in nuclear speckles.
Tissue Location Expression restricted to adult bone marrow and fetal liver. Not expressed in myeloid nor lymphoid cell lines
Research Areas
Citations (0)

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This gene encodes a hematopoietic-specific transcriptionfactor that induces high-level expression of adult beta-globin andother erythroid genes. The zinc-finger protein binds to the DNAsequence CCACACCCT found in the beta hemoglobin promoter.Heterozygous loss-of-function mutations in this gene result in thedominant In(Lu) blood phenotype.


Borg, J., et al. Nat. Genet. 42(9):801-805(2010)Zhou, D., et al. Nat. Genet. 42(9):742-744(2010)Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Papachatzopoulou, A., et al. Hemoglobin 34(4):333-342(2010)Ganesh, S.K., et al. Nat. Genet. 41(11):1191-1198(2009)

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$ 80.00
Cat# BP14499b
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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