|Other Names||Krueppel-like factor 1, Erythroid krueppel-like transcription factor, EKLF, KLF1, EKLF|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Transcription regulator of erythrocyte development that probably serves as a general switch factor during erythropoiesis. Is a dual regulator of fetal-to-adult globin switching. Binds to the CACCC box in the beta-globin gene promoter and acts as a preferential activator of this gene. Furthermore, it binds to the BCL11A promoter and activates expression of BCL11A, which in turn represses the HBG1 and HBG2 genes. This dual activity ensures that, in most adults, fetal hemoglobin levels are low. Able to activate CD44 and AQP1 promoters. When sumoylated, acts as a transcriptional repressor by promoting interaction with CDH2/MI2beta and also represses megakaryocytic differentiation.|
|Cellular Location||Nucleus. Note=Colocalizes with SUMO1 in nuclear speckles.|
|Tissue Location||Expression restricted to adult bone marrow and fetal liver. Not expressed in myeloid nor lymphoid cell lines|
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This gene encodes a hematopoietic-specific transcriptionfactor that induces high-level expression of adult beta-globin andother erythroid genes. The zinc-finger protein binds to the DNAsequence CCACACCCT found in the beta hemoglobin promoter.Heterozygous loss-of-function mutations in this gene result in thedominant In(Lu) blood phenotype.
Borg, J., et al. Nat. Genet. 42(9):801-805(2010)Zhou, D., et al. Nat. Genet. 42(9):742-744(2010)Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Papachatzopoulou, A., et al. Hemoglobin 34(4):333-342(2010)Ganesh, S.K., et al. Nat. Genet. 41(11):1191-1198(2009)
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