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PYGM Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P11217 |
|---|---|
| Clone Names | 70319188 |
| Gene ID | 5837 |
|---|---|
| Other Names | Glycogen phosphorylase, muscle form, Myophosphorylase, PYGM |
| Target/Specificity | The synthetic peptide sequence used to generate the antibody AP1450c was selected from the Center region of human PYGM. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | PYGM (HGNC:9726) |
|---|---|
| Function | Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
PYGM catalyzes and regulates the breakdown of glycogen to glucose-1-phosphate. Defects in PYGM are the cause of glycogen storage disease type 5 (GSD5), also known as McArdle disease. GSD5 is a metabolic disorder resulting in myopathy characterized by exercise intolerance, cramps, muscle weakness and recurrent myoglobinuria.
References
Tsoi, S.C., et al., J. Soc. Gynecol. Investig. 10(8):496-502 (2003).Bruno, C., et al., Neuromuscul. Disord. 12(5):498-500 (2002).Hadjigeorgiou, G.M., et al., Neuromuscul. Disord. 12(9):824-827 (2002).Deschauer, M., et al., Mol. Genet. Metab. 74(4):489-491 (2001).Kubisch, C., et al., Hum. Mutat. 12(1):27-32 (1998).
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