|Other Names||SEC23-interacting protein, p125, SEC23IP|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Plays a role in the organization of endoplasmic reticulum exit sites. Specifically binds to phosphatidylinositol 3-phosphate (PI(3)P), phosphatidylinositol 4-phosphate (PI(4)P) and phosphatidylinositol 5-phosphate (PI(5)P).|
|Cellular Location||Cytoplasmic vesicle, COPII-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side Endoplasmic reticulum|
|Tissue Location||Ubiquitously expressed with stronger levels detected in heart, liver and skeletal muscle|
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COPII-coated vesicles are involved in protein transportfrom the endoplasmic reticulum to the Golgi apparatus. The proteinencoded by this gene was identified by its interaction with a mouseprotein similar to yeast Sec23p, an essential component of theCOPII. This protein shares significant similarity withphospholipid-modifying proteins, especially phosphatidic acidpreferring-phospholipase A1. Overexpression of this protein hasbeen shown to cause disorganization of the endoplasmicreticulum-Golgi intermediate compartment and Golgi apparatus, whichsuggests its role in the early secretory pathway. [provided byRefSeq].
Ong, Y.S., et al. J. Cell Biol. 190(3):331-345(2010)Trynka, G., et al. Gut 58(8):1078-1083(2009)Li, H., et al. J. Biol. Chem. 281(21):14748-14755(2006)Grupe, A., et al. Am. J. Hum. Genet. 78(1):78-88(2006)Shimoi, W., et al. J. Biol. Chem. 280(11):10141-10148(2005)
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