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SEC23IP Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q9Y6Y8 |
|---|---|
| Clone Names | 100517235 |
| Gene ID | 11196 |
|---|---|
| Other Names | SEC23-interacting protein, p125, SEC23IP |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | SEC23IP |
|---|---|
| Function | Plays a role in the organization of endoplasmic reticulum exit sites. Specifically binds to phosphatidylinositol 3-phosphate (PI(3)P), phosphatidylinositol 4-phosphate (PI(4)P) and phosphatidylinositol 5-phosphate (PI(5)P). |
| Cellular Location | Cytoplasmic vesicle, COPII-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Endoplasmic reticulum |
| Tissue Location | Ubiquitously expressed with stronger levels detected in heart, liver and skeletal muscle |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
COPII-coated vesicles are involved in protein transportfrom the endoplasmic reticulum to the Golgi apparatus. The proteinencoded by this gene was identified by its interaction with a mouseprotein similar to yeast Sec23p, an essential component of theCOPII. This protein shares significant similarity withphospholipid-modifying proteins, especially phosphatidic acidpreferring-phospholipase A1. Overexpression of this protein hasbeen shown to cause disorganization of the endoplasmicreticulum-Golgi intermediate compartment and Golgi apparatus, whichsuggests its role in the early secretory pathway. [provided byRefSeq].
References
Ong, Y.S., et al. J. Cell Biol. 190(3):331-345(2010)Trynka, G., et al. Gut 58(8):1078-1083(2009)Li, H., et al. J. Biol. Chem. 281(21):14748-14755(2006)Grupe, A., et al. Am. J. Hum. Genet. 78(1):78-88(2006)Shimoi, W., et al. J. Biol. Chem. 280(11):10141-10148(2005)
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