|Other Names||Transcription initiation factor TFIID subunit 9B, Neuronal cell death-related protein 7, DN-7, Transcription initiation factor TFIID subunit 9-like, Transcription-associated factor TAFII31L, TAF9B, TAF9L|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Essential for cell viability. TAF9 and TAF9B are involved in transcriptional activation as well as repression of distinct but overlapping sets of genes. May have a role in gene regulation associated with apoptosis. TAFs are components of the transcription factor IID (TFIID) complex, the TBP-free TAFII complex (TFTC), the PCAF histone acetylase complex and the STAGA transcription coactivator-HAT complex. TFIID or TFTC are essential for the regulation of RNA polymerase II-mediated transcription.|
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Provided below are standard protocols that you may find useful for product applications.
Initiation of transcription by RNA polymerase II requiresthe activities of more than 70 polypeptides. The protein thatcoordinates these activities is transcription factor IID (TFIID),which binds to the core promoter to position the polymeraseproperly, serves as the scaffold for assembly of the remainder ofthe transcription complex, and acts as a channel for regulatorysignals. TFIID is composed of the TATA-binding protein (TBP) and agroup of evolutionarily conserved proteins known as TBP-associatedfactors or TAFs. TAFs may participate in basal transcription, serveas coactivators, function in promoter recognition or modify generaltranscription factors (GTFs) to facilitate complex assembly andtranscription initiation. This gene encodes a protein that issimilar to one of the small subunits of TFIID, TBP-associatedfactor 9, and is also a subunit of TFIID. TAF9 and TAF9b share somefunctions but also have distinct roles in the transcriptionalregulatory process.
Frontini, M., et al. Mol. Cell. Biol. 25(11):4638-4649(2005)Ross, M.T., et al. Nature 434(7031):325-337(2005)Chen, Z., et al. J. Biol. Chem. 278(37):35172-35183(2003)Albright, S.R., et al. Gene 242 (1-2), 1-13 (2000) :Lu, H., et al. Proc. Natl. Acad. Sci. U.S.A. 92(11):5154-5158(1995)
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