|Other Names||Lysosomal thioesterase PPT2, PPT-2, 312-, S-thioesterase G14, PPT2|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Removes thioester-linked fatty acyl groups from various substrates including S-palmitoyl-CoA. Has the highest S- thioesterase activity for the acyl groups palmitic and myristic acid followed by other short- and long-chain acyl substrates. However, because of structural constraints, is unable to remove palmitate from peptides or proteins.|
|Tissue Location||Broadly expressed, with highest levels in skeletal muscle.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the palmitoyl-proteinthioesterase family. The encoded glycosylated lysosomal protein haspalmitoyl-CoA hydrolase activity in vitro, but does not hydrolyzepalmitate from cysteine residues in proteins. Three transcriptvariants encoding different isoforms have been described for thisgene, with one of the isoforms being inactive. [provided byRefSeq].
Hancock, D.B., et al. Nat. Genet. 42(1):45-52(2010)Barcellos, L.F., et al. PLoS Genet. 5 (10), E1000696 (2009) :McKinnon, E., et al. Diabetes Obes Metab 11 SUPPL 1, 92-100 (2009) :Lamesch, P., et al. Genomics 89(3):307-315(2007)Sleat, D.E., et al. Mol. Cell Proteomics 5(4):686-701(2006)
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