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DPF2 Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q92785 |
|---|---|
| Other Accession | NP_006259 |
| Clone Names | 70319112 |
| Gene ID | 5977 |
|---|---|
| Other Names | Zinc finger protein ubi-d4, Apoptosis response zinc finger protein, BRG1-associated factor 45D, BAF45D, D4, zinc and double PHD fingers family 2, Protein requiem, DPF2, BAF45D, REQ, UBID4 |
| Target/Specificity | The synthetic peptide sequence used to generate the antibody AP1451c was selected from the Center region of human DPF2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | DPF2 |
|---|---|
| Synonyms | BAF45D, REQ, UBID4 |
| Function | Plays an active role in transcriptional regulation by binding modified histones H3 and H4 (PubMed:28533407, PubMed:27775714). Is a negative regulator of myeloid differentiation of hematopoietic progenitor cells (PubMed:28533407). Might also have a role in the development and maturation of lymphoid cells (By similarity). Involved in the regulation of non-canonical NF-kappa-B pathway (PubMed:20460684). |
| Cellular Location | Nucleus. Cytoplasm |
| Tissue Location | Ubiquitous. |
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Provided below are standard protocols that you may find useful for product applications.
Background
DPF2 is a member of the d4 domain family, characterized by a zinc finger-like structural motif. This protein functions as a transcription factor which is necessary for the apoptotic response following deprivation of survival factors. It likely serves a regulatory role in rapid hematopoietic cell growth and turnover. The DPF2 gene is considered a candidate gene for multiple endocrine neoplasia type I, an inherited cancer syndrome involving multiple parathyroid, enteropancreatic, and pituitary tumors.
References
Ninkina, N.N., et al., Mamm. Genome 12(11):862-866 (2001).Gabig, T.G., et al., Mamm. Genome 9(8):660-665 (1998).Guru, S.C., et al., Genome Res. 7(7):725-735 (1997).Chestkov, A.V., et al., Genomics 36(1):174-177 (1996).Gabig, T.G., et al., J. Biol. Chem. 269(47):29515-29519 (1994).
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