|Other Names||Zinc finger protein ubi-d4, Apoptosis response zinc finger protein, BRG1-associated factor 45D, BAF45D, D4, zinc and double PHD fingers family 2, Protein requiem, DPF2, BAF45D, REQ, UBID4|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP1451c was selected from the Center region of human DPF2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||BAF45D, REQ, UBID4|
|Function||May be a transcription factor required for the apoptosis response following survival factor withdrawal from myeloid cells. Might also have a role in the development and maturation of lymphoid cells.|
|Cellular Location||Nucleus. Cytoplasm. Note=30% nuclear. 70% cytoplasmic|
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DPF2 is a member of the d4 domain family, characterized by a zinc finger-like structural motif. This protein functions as a transcription factor which is necessary for the apoptotic response following deprivation of survival factors. It likely serves a regulatory role in rapid hematopoietic cell growth and turnover. The DPF2 gene is considered a candidate gene for multiple endocrine neoplasia type I, an inherited cancer syndrome involving multiple parathyroid, enteropancreatic, and pituitary tumors.
Ninkina, N.N., et al., Mamm. Genome 12(11):862-866 (2001).Gabig, T.G., et al., Mamm. Genome 9(8):660-665 (1998).Guru, S.C., et al., Genome Res. 7(7):725-735 (1997).Chestkov, A.V., et al., Genomics 36(1):174-177 (1996).Gabig, T.G., et al., J. Biol. Chem. 269(47):29515-29519 (1994).
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