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PVRL1 Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q15223 |
|---|---|
| Clone Names | 100525048 |
| Gene ID | 5818 |
|---|---|
| Other Names | Nectin-1, Herpes virus entry mediator C, Herpesvirus entry mediator C, HveC, Herpesvirus Ig-like receptor, HIgR, Poliovirus receptor-related protein 1, CD111, PVRL1, HVEC, PRR1 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | NECTIN1 (HGNC:9706) |
|---|---|
| Synonyms | HVEC, PRR1, PVRL1 |
| Function | Promotes cell-cell contacts by forming homophilic or heterophilic trans-dimers. Heterophilic interactions have been detected between NECTIN1 and NECTIN3 and between NECTIN1 and NECTIN4. Has some neurite outgrowth-promoting activity. |
| Cellular Location | [Isoform Alpha]: Cell membrane; Single-pass type I membrane protein. Presynaptic cell membrane [Isoform Gamma]: Secreted. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes an adhesion protein that plays a role inthe organization of adherens junctions and tight junctions inepithelial and endothelial cells. The protein is acalcium(2+)-independent cell-cell adhesion molecule that belongs tothe immunoglobulin superfamily and has 3 extracellularimmunoglobulin-like loops, a single transmembrane domain (in someisoforms), and a cytoplasmic region. This protein acts as areceptor for glycoprotein D (gD) of herpes simplex viruses 1 and 2(HSV-1, HSV-2), and pseudorabies virus (PRV) and mediates viralentry into epithelial and neuronal cells. Mutations in this genecause cleft lip and palate/ectodermal dysplasia 1 syndrome (CLPED1)as well as non-syndromic cleft lip with or without cleft palate(CL/P). Alternative splicing results in multiple transcriptvariants encoding proteins with distinct C-termini. [provided byRefSeq].
References
Nikopensius, T., et al. Birth Defects Res. Part A Clin. Mol. Teratol. 88(9):748-756(2010)Vetter, G., et al. Oncogene 29(31):4436-4448(2010)Kim, J., et al. J. Biol. Chem. 285(30):22919-22926(2010)Jagomagi, T., et al. Eur. J. Oral Sci. 118(3):213-220(2010)Jugessur, A., et al. PLoS ONE 5 (7), E11493 (2010) :
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