|Other Names||Nectin-1, Herpes virus entry mediator C, Herpesvirus entry mediator C, HveC, Herpesvirus Ig-like receptor, HIgR, Poliovirus receptor-related protein 1, CD111, PVRL1, HVEC, PRR1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Promotes cell-cell contacts by forming homophilic or heterophilic trans-dimers. Heterophilic interactions have been detected between PVRL1/nectin-1 and PVRL3/nectin-3 and between PVRL1/nectin-1 and PVRL4/nectin-4. Functions as an entry receptor for herpes simplex virus and pseudorabies virus. Has some neurite outgrowth-promoting activity.|
|Cellular Location||Isoform Alpha: Cell membrane; Single-pass type I membrane protein. Cell junction, synapse, presynaptic cell membrane Isoform Gamma: Secreted.|
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This gene encodes an adhesion protein that plays a role inthe organization of adherens junctions and tight junctions inepithelial and endothelial cells. The protein is acalcium(2+)-independent cell-cell adhesion molecule that belongs tothe immunoglobulin superfamily and has 3 extracellularimmunoglobulin-like loops, a single transmembrane domain (in someisoforms), and a cytoplasmic region. This protein acts as areceptor for glycoprotein D (gD) of herpes simplex viruses 1 and 2(HSV-1, HSV-2), and pseudorabies virus (PRV) and mediates viralentry into epithelial and neuronal cells. Mutations in this genecause cleft lip and palate/ectodermal dysplasia 1 syndrome (CLPED1)as well as non-syndromic cleft lip with or without cleft palate(CL/P). Alternative splicing results in multiple transcriptvariants encoding proteins with distinct C-termini. [provided byRefSeq].
Nikopensius, T., et al. Birth Defects Res. Part A Clin. Mol. Teratol. 88(9):748-756(2010)Vetter, G., et al. Oncogene 29(31):4436-4448(2010)Kim, J., et al. J. Biol. Chem. 285(30):22919-22926(2010)Jagomagi, T., et al. Eur. J. Oral Sci. 118(3):213-220(2010)Jugessur, A., et al. PLoS ONE 5 (7), E11493 (2010) :
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