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PTPRN Antibody (Center) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q16849
Clone Names 100525057
Peptide ID 100525057
Additional Information
Gene ID 5798
Other Names Receptor-type tyrosine-protein phosphatase-like N, R-PTP-N, Islet cell antigen 512, ICA 512, Islet cell autoantigen 3, PTP IA-2, PTPRN, ICA3, ICA512
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms ICA3, ICA512
Function Implicated in neuroendocrine secretory processes. May be involved in processes specific for neurosecretory granules, such as their biogenesis, trafficking or regulated exocytosis or may have a general role in neuroendocrine functions. Seems to lack intrinsic enzyme activity. May play a role in the regulation of secretory granules via its interaction with SNTB2.
Cellular Location Membrane; Single-pass type I membrane protein. Note=Neuroendocrine secretory granules
Tissue Location Expression is restricted to neuroendocrine cells. Found in pancreas, brain and pituitary
Research Areas
Citations (0)

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The protein encoded by this gene is a member of theprotein tyrosine phosphatase (PTP) family. PTPs are known to besignaling molecules that regulate a variety of cellular processesincluding cell growth, differentiation, mitotic cycle, andoncogenic transformation. This PTP possesses an extracellularregion, a single transmembrane region, and a single catalyticdomain, and thus represents a receptor-type PTP. This PTP was foundto be an autoantigen that is reactive with insulin-dependentdiabetes mellitus (IDDM) patient sera, and thus may be a potentialtarget of autoimmunity in diabetes mellitus.


Yu, L., et al. J. Immunol. Methods 353 (1-2), 20-23 (2010) :Honeyman, M.C., et al. J. Immunol. 184(4):2204-2210(2010)Weenink, S.M., et al. J. Autoimmun. 33(2):147-154(2009)Burbelo, P.D., et al. Diabetes Care 31(9):1824-1826(2008)Williams, A.J., et al. Diabetologia 51(8):1444-1448(2008)

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$ 80.00
Cat# BP14523c
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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