|Other Names||Receptor-type tyrosine-protein phosphatase-like N, R-PTP-N, Islet cell antigen 512, ICA 512, Islet cell autoantigen 3, PTP IA-2, PTPRN, ICA3, ICA512|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Implicated in neuroendocrine secretory processes. May be involved in processes specific for neurosecretory granules, such as their biogenesis, trafficking or regulated exocytosis or may have a general role in neuroendocrine functions. Seems to lack intrinsic enzyme activity. May play a role in the regulation of secretory granules via its interaction with SNTB2.|
|Cellular Location||Membrane; Single-pass type I membrane protein. Note=Neuroendocrine secretory granules|
|Tissue Location||Expression is restricted to neuroendocrine cells. Found in pancreas, brain and pituitary|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a member of theprotein tyrosine phosphatase (PTP) family. PTPs are known to besignaling molecules that regulate a variety of cellular processesincluding cell growth, differentiation, mitotic cycle, andoncogenic transformation. This PTP possesses an extracellularregion, a single transmembrane region, and a single catalyticdomain, and thus represents a receptor-type PTP. This PTP was foundto be an autoantigen that is reactive with insulin-dependentdiabetes mellitus (IDDM) patient sera, and thus may be a potentialtarget of autoimmunity in diabetes mellitus.
Yu, L., et al. J. Immunol. Methods 353 (1-2), 20-23 (2010) :Honeyman, M.C., et al. J. Immunol. 184(4):2204-2210(2010)Weenink, S.M., et al. J. Autoimmun. 33(2):147-154(2009)Burbelo, P.D., et al. Diabetes Care 31(9):1824-1826(2008)Williams, A.J., et al. Diabetologia 51(8):1444-1448(2008)
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