|Other Names||Oncostatin-M, OSM, OSM|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Growth regulator. Inhibits the proliferation of a number of tumor cell lines. Stimulates proliferation of AIDS-KS cells. It regulates cytokine production, including IL-6, G-CSF and GM-CSF from endothelial cells. Uses both type I OSM receptor (heterodimers composed of LIPR and IL6ST) and type II OSM receptor (heterodimers composed of OSMR and IL6ST). Involved in the maturation of fetal hepatocytes, thereby promoting liver development and regeneration (By similarity).|
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Provided below are standard protocols that you may find useful for product applications.
Oncostatin M is a member of a cytokine family thatincludes leukemia-inhibitory factor, granulocyte colony-stimulatingfactor, and interleukin 6. This gene encodes a growth regulatorwhich inhibits the proliferation of a number of tumor cell lines.It regulates cytokine production, including IL-6, G-CSF and GM-CSFfrom endothelial cells.
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Thorat Manojkumar, S., et al. Cytokine 50(3):248-252(2010)Pradeep, A.R., et al. Biomarkers 15(3):277-282(2010)Davila, S., et al. Genes Immun. 11(3):232-238(2010)Lee, G., et al. J. Obstet. Gynaecol. Res. 35(5):869-875(2009)
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