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POLI Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q9UNA4 |
|---|---|
| Clone Names | 100525132 |
| Gene ID | 11201 |
|---|---|
| Other Names | DNA polymerase iota, Eta2, RAD30 homolog B, POLI, RAD30B |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | POLI |
|---|---|
| Synonyms | RAD30B |
| Function | Error-prone DNA polymerase specifically involved in DNA repair (PubMed:11013228, PubMed:11387224). Plays an important role in translesion synthesis, where the normal high-fidelity DNA polymerases cannot proceed and DNA synthesis stalls (PubMed:11013228, PubMed:11387224, PubMed:14630940, PubMed:15199127). Favors Hoogsteen base-pairing in the active site (PubMed:15254543). Inserts the correct base with high-fidelity opposite an adenosine template (PubMed:15254543). Exhibits low fidelity and efficiency opposite a thymidine template, where it will preferentially insert guanosine (PubMed:11013228). May play a role in hypermutation of immunoglobulin genes (PubMed:12410315). Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but may not have lyase activity (PubMed:11251121, PubMed:14630940). |
| Cellular Location | Nucleus. Note=Binding to ubiquitin mediates localization to replication forks after UV-induced DNA damage. {ECO:0000250|UniProtKB:Q6R3M4} |
| Tissue Location | Ubiquitous. Highly expressed in testis. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Error-prone DNA polymerase specifically involved in DNA repair. Plays an important role in translesion synthesis, where the normal high-fidelity DNA polymerases cannot proceed and DNA synthesis stalls. Favors Hoogsteen base-pairing in the active site. Inserts the correct base with high-fidelity opposite an adenosine template. Exhibits low fidelity and efficiency opposite a thymidine template, where it will preferentially insert guanosine. May play a role in hypermutation of immunogobulin genes. Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but may not have lyase activity.
References
Arora, M., et al. Leukemia 24(8):1470-1475(2010)Thyagarajan, B., et al. Biol. Blood Marrow Transplant. 16(8):1084-1089(2010)Kazakov, A.A., et al. Biochemistry Mosc. 75(7):905-911(2010)Liu, C.Y., et al. Carcinogenesis 31(7):1259-1263(2010)Monsees, G.M., et al. Breast Cancer Res. Treat. (2010) In press :
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