|Other Names||Sodium/glucose cotransporter 1, Na(+)/glucose cotransporter 1, High affinity sodium-glucose cotransporter, Solute carrier family 5 member 1, SLC5A1, NAGT, SGLT1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Actively transports glucose into cells by Na(+) cotransport with a Na(+) to glucose coupling ratio of 2:1. Efficient substrate transport in mammalian kidney is provided by the concerted action of a low affinity high capacity and a high affinity low capacity Na(+)/glucose cotransporter arranged in series along kidney proximal tubules.|
|Cellular Location||Membrane; Multi-pass membrane protein.|
|Tissue Location||Expressed mainly in intestine and kidney.|
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This gene encodes a member of the sodium-dependent glucosetransporter (SGLT) family. The encoded integral membrane protein isthe primary mediator of dietary glucose and galactose uptake fromthe intestinal lumen. Mutations in this gene have been associatedwith glucose-galactose malabsorption.
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Sopjani, M., et al. Mol. Membr. Biol. 27 (2-3), 137-144 (2010) :Longpre, J.P., et al. Biophys. J. 98(2):231-239(2010)Yokoyama, K., et al. Nephron Clin Pract 115 (4), C237-C243 (2010) :Banerjee, S.K., et al. Cardiovasc. Res. 84(1):111-118(2009)
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