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MARCH8 Antibody (Center) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q5T0T0
Other Accession NP_659458
Clone Names 70319134
Peptide ID 70319134
Additional Information
Gene ID 220972
Other Names E3 ubiquitin-protein ligase MARCH8, 632-, Cellular modulator of immune recognition, c-MIR, Membrane-associated RING finger protein 8, Membrane-associated RING-CH protein VIII, MARCH-VIII, RING finger protein 178, MARCH8, MIR, RNF178
Target/Specificity The synthetic peptide sequence used to generate the antibody AP1452c was selected from the Center region of human MARCH8. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms MIR, RNF178
Function E3 ubiquitin-protein ligase that mediates ubiquitination of CD86 and MHC class II proteins, such as HLA-DR alpha and beta, and promotes their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. May also promote ubiquitination and endocytosis of TFRC and FAS.
Cellular Location Cytoplasmic vesicle membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein Early endosome membrane; Multi-pass membrane protein
Tissue Location Broadly expressed. Present in immature dendritic cells (at protein level).
Research Areas
Citations (0)

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MARCH8 is an E3 ubiquitin-protein ligase that may regulate immune responses by promoting ubiquitination of MHC-II and CD86, which leads to their subsequent endocytosis and lysosomal degradation. May also promote ubiquitination and endocytosis of TFRC and FAS. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates.


Bartee, E., et al., J. Virol. 78(3):1109-1120 (2004).Goto, E., et al., J. Biol. Chem. 278(17):14657-14668 (2003).

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$ 80.00
Cat# BP1452c
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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