|Other Names||Plasma membrane calcium-transporting ATPase 4, PMCA4, Matrix-remodeling-associated protein 1, Plasma membrane calcium ATPase isoform 4, Plasma membrane calcium pump isoform 4, ATP2B4, ATP2B2, MXRA1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium out of the cell.|
|Cellular Location||Cell membrane; Multi-pass membrane protein.|
|Tissue Location||Isoform XB is the most abundant isoform and is expressed ubiquitously. Isoforms containing segment Z have only been detected in heart, while isoforms containing segment a have been found in heart, stomach and brain cortex|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene belongs to the family ofP-type primary ion transport ATPases characterized by the formationof an aspartyl phosphate intermediate during the reaction cycle.These enzymes remove bivalent calcium ions from eukaryotic cellsagainst very large concentration gradients and play a critical rolein intracellular calcium homeostasis. The mammalian plasma membranecalcium ATPase isoforms are encoded by at least four separate genesand the diversity of these enzymes is further increased byalternative splicing of transcripts. The expression of differentisoforms and splice variants is regulated in a developmental,tissue- and cell type-specific manner, suggesting that these pumpsare functionally adapted to the physiological needs of particularcells and tissues. This gene encodes the plasma membrane calciumATPase isoform 4. Alternatively spliced transcript variantsencoding different isoforms have been identified. [provided byRefSeq].
Holton, M., et al. Cardiovasc. Res. 87(3):440-448(2010)Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Juranic, N., et al. J. Biol. Chem. 285(6):4015-4024(2010)Ehret, G.B., et al. Eur. J. Hum. Genet. 17(12):1650-1657(2009)Aung, C.S., et al. Carcinogenesis 30(11):1962-1969(2009)
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