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ATP2B4 Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P23634 |
|---|---|
| Clone Names | 100525155 |
| Gene ID | 493 |
|---|---|
| Other Names | Plasma membrane calcium-transporting ATPase 4, PMCA4, Matrix-remodeling-associated protein 1, Plasma membrane calcium ATPase isoform 4, Plasma membrane calcium pump isoform 4, ATP2B4, ATP2B2, MXRA1 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | ATP2B4 (HGNC:817) |
|---|---|
| Synonyms | ATP2B2, MXRA1 |
| Function | Calcium/calmodulin-regulated and magnesium-dependent enzyme that catalyzes the hydrolysis of ATP coupled with the transport of calcium out of the cell (PubMed:8530416). By regulating sperm cell calcium homeostasis, may play a role in sperm motility (By similarity). |
| Cellular Location | Cell membrane; Multi-pass membrane protein. Cell projection, cilium, flagellum membrane {ECO:0000250|UniProtKB:Q6Q477}; Multi-pass membrane protein |
| Tissue Location | Isoform XB is the most abundant isoform and is expressed ubiquitously. Isoforms containing segment Z have only been detected in heart, while isoforms containing segment a have been found in heart, stomach and brain cortex. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene belongs to the family ofP-type primary ion transport ATPases characterized by the formationof an aspartyl phosphate intermediate during the reaction cycle.These enzymes remove bivalent calcium ions from eukaryotic cellsagainst very large concentration gradients and play a critical rolein intracellular calcium homeostasis. The mammalian plasma membranecalcium ATPase isoforms are encoded by at least four separate genesand the diversity of these enzymes is further increased byalternative splicing of transcripts. The expression of differentisoforms and splice variants is regulated in a developmental,tissue- and cell type-specific manner, suggesting that these pumpsare functionally adapted to the physiological needs of particularcells and tissues. This gene encodes the plasma membrane calciumATPase isoform 4. Alternatively spliced transcript variantsencoding different isoforms have been identified. [provided byRefSeq].
References
Holton, M., et al. Cardiovasc. Res. 87(3):440-448(2010)Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Juranic, N., et al. J. Biol. Chem. 285(6):4015-4024(2010)Ehret, G.B., et al. Eur. J. Hum. Genet. 17(12):1650-1657(2009)Aung, C.S., et al. Carcinogenesis 30(11):1962-1969(2009)
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