|Other Names||U4/U6 small nuclear ribonucleoprotein Prp31, Pre-mRNA-processing factor 31, Serologically defined breast cancer antigen NY-BR-99, U4/U6 snRNP 61 kDa protein, Protein 61K, hPrp31, PRPF31, PRP31|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Involved in pre-mRNA splicing. Required for the assembly of the U4/U5/U6 tri-snRNP complex, one of the building blocks of the spliceosome.|
|Cellular Location||Nucleus speckle. Nucleus, Cajal body. Note=Predominantly found in speckles and in Cajal bodies|
|Tissue Location||Ubiquitously expressed.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a component of the spliceosome complexand is one of several retinitis pigmentosa-causing genes. When thegene product is added to the spliceosome complex, activationoccurs.
Schneider, M., et al. Nat. Struct. Mol. Biol. 17(2):216-221(2010)Bujakowska, K., et al. Invest. Ophthalmol. Vis. Sci. 50(12):5927-5933(2009)Potkin, S.G., et al. PLoS ONE 4 (8), E6501 (2009) :Liu, S., et al. Science 316(5821):115-120(2007)Sullivan, L.S., et al. Invest. Ophthalmol. Vis. Sci. 47(10):4579-4588(2006)
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