METTL7A Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q9H8H3 |
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Gene ID | 25840 |
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Other Names | Methyltransferase-like protein 7A, 211-, Protein AAM-B, METTL7A |
Target/Specificity | The synthetic peptide sequence used to generate the antibody AP1454c was selected from the Center region of human METTL7A. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | TMT1A {ECO:0000303|PubMed:37137720, ECO:0000312|HGNC:HGNC:24550} |
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Function | Thiol S-methyltransferase that catalyzes the transfer of a methyl group from S-adenosyl-L-methionine to alkyl and phenolic thiol- containing acceptor substrates. Together with TMT1B accounts for most of S-thiol methylation activity in the endoplasmic reticulum of hepatocytes (PubMed:37137720). Able to methylate the N6 position of adenosine residues in long non-coding RNAs (lncRNAs) (PubMed:34980213). May facilitate lncRNAs transfer into exosomes at the tumor-stroma interface (PubMed:34980213). Promotes osteogenic and odontogenic differentiation by regulating the expression of genes involved in stem cell differentiation and survival (PubMed:34226523, PubMed:34790668). Targeted from the endoplasmic reticulum to lipid droplets, where it recruits cellular proteins to form functional organelles (PubMed:19773358). |
Cellular Location | Lipid droplet. Endoplasmic reticulum. Membrane. Microsome Cytoplasm, cytosol. Note=Inserted in the ER membrane and migrates from the inserted site to lipid droplet |
Tissue Location | Expressed in the liver. |
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Provided below are standard protocols that you may find useful for product applications.
Background
METTL7A is a methyltransferase-like protein and members of this family are SAM dependent methyltransferases.
References
Clark,H.F.,Genome Res. 13 (10), 2265-2270 (2003)
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