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UBA1 Antibody (N-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession P22314
Clone Names 100507119
Peptide ID 100507119
Additional Information
Gene ID 7317
Other Names Ubiquitin-like modifier-activating enzyme 1, Protein A1S9, Ubiquitin-activating enzyme E1, UBA1, A1S9T, UBE1
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name UBA1
Synonyms A1S9T, UBE1
Function Catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation through the ubiquitin- proteasome system (PubMed:1606621, PubMed:1447181). Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP (PubMed:1447181). Essential for the formation of radiation- induced foci, timely DNA repair and for response to replication stress. Promotes the recruitment of TP53BP1 and BRCA1 at DNA damage sites (PubMed:22456334).
Cellular Location Cytoplasm. Mitochondrion. Nucleus Isoform 2: Cytoplasm
Tissue Location Detected in erythrocytes (at protein level). Ubiquitous.
Research Areas
Citations (0)

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The protein encoded by this gene catalyzes the first stepin ubiquitin conjugation to mark cellular proteins for degradation.This gene complements an X-linked mouse temperature-sensitivedefect in DNA synthesis, and thus may function in DNA repair. It ispart of a gene cluster on chromosome Xp11.23. Alternatively splicedtranscript variants that encode the same protein have beendescribed.


Burkhardt, J., et al. J. Rheumatol. 36(10):2149-2157(2009)Su, Z.L., et al. Leuk. Lymphoma 49(9):1821-1822(2008)Ramser, J., et al. Am. J. Hum. Genet. 82(1):188-193(2008)Carbia-Nagashima, A., et al. Cell 131(2):309-323(2007)Jin, J., et al. Nature 447(7148):1135-1138(2007)

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$ 80.00
Cat# BP14555a
Availability: In Stock
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