|Other Names||Glycylpeptide N-tetradecanoyltransferase 2, Myristoyl-CoA:protein N-myristoyltransferase 2, NMT 2, Peptide N-myristoyltransferase 2, Type II N-myristoyltransferase, NMT2|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Adds a myristoyl group to the N-terminal glycine residue of certain cellular and viral proteins.|
|Cellular Location||Cytoplasm. Membrane; Peripheral membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
N-myristoyltransferase (NMT) catalyzes the reaction ofN-terminal myristoylation of many signaling proteins. It transfersmyristic acid from myristoyl coenzyme A to the amino group of aprotein's N-terminal glycine residue. Biochemical evidenceindicates the presence of several distinct NMTs, varying inapparent molecular weight and /or subcellular distribution. Thepredicted 498-amino acid of human NMT2 protein shares 77% and 96%sequence identity with human NMT1 and mouse Nmt2 comprise twodistinct families of N-myristoyltransferases.
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)Seaton, K.E., et al. J. Gen. Virol. 89 (PT 1), 288-296 (2008) :Quintero-Rivera, F., et al. Am. J. Med. Genet. A 143A (15), 1796-1798 (2007) :
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